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DOI: 10.14670/HH-11-918
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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Wang, Miaohong | - |
dc.contributor.author | Tan, Jin | - |
dc.contributor.author | Miao, Yuyang | - |
dc.contributor.author | Li, Mengmeng | - |
dc.contributor.author | Zhang, Qiang | - |
dc.date.accessioned | 2022-04-04T10:39:53Z | - |
dc.date.available | 2022-04-04T10:39:53Z | - |
dc.date.issued | 2018 | - |
dc.identifier.citation | Histology and Histopathology, Vol.33, nº3, (2018) | es |
dc.identifier.issn | 1699-5848 | - |
dc.identifier.issn | 0213-3911 | - |
dc.identifier.uri | http://hdl.handle.net/10201/118683 | - |
dc.description.abstract | Hypoxia is a kind of common pathological condition existing in various diseases such as sleep apnea syndrome, myocardial infarction and stroke, which can precipitate the onset of diseases through inducing cell apoptosis. Ca2+ is the ubiquitous message in cell. Given the crucial role of Ca2+ in physiology, intracellular Ca2+ overload is a significant regulator of apoptosis. Numerous experiments show that hypoxia may cause changes of multiple cellular Ca2+ channels, for instance, Na+/Ca2+ Exchanger (NCX), L-type voltage dependent Ca2+ channel (L-VDCC), inositol triphosphate receptors (IP3R) and so on, which contribute to intracellular Ca2+ overload, thus eventually triggering cell apoptosis. However, the mechanisms underlying different Ca2+ channels involved in hypoxic apoptosis are complex. For example, chronic hypoxia or acute hypoxia may select different Ca2+ channels to influence cell apoptosis. In addition, intracellular Ca2+ overload may initiate different apoptotic pathways due to hypoxic duration. Furthermore, different locations in the cell of specific Ca2+ channels activated by hypoxia will determine different apoptosis signaling pathways. Moreover, activation of different Ca2+ channel isoforms will result in different outcomes of the cell under hypoxia. Hence, we aim to highlight the potential mechanisms of the main Ca2+ channels in regulation of apoptosis under hypoxic stress. | es |
dc.format | application/pdf | es |
dc.format.extent | 10 | es |
dc.language | eng | es |
dc.publisher | Universidad de Murcia. Departamento de Biología Celular e Histología | es |
dc.relation | Sin financiación externa a la Universidad | es |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Hypoxia | es |
dc.subject | Apoptosis | es |
dc.subject | Ca2+ | es |
dc.subject | Ca2+ channels | es |
dc.subject.other | CDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología | es |
dc.title | Role of Ca2+ and ion channels in the regulation of apoptosis under hypoxia | es |
dc.type | info:eu-repo/semantics/article | es |
dc.identifier.doi | DOI: 10.14670/HH-11-918 | - |
Aparece en las colecciones: | Vol.33, nº3 (2018) |
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Wang-33-237-246-2018.pdf | 4,51 MB | Adobe PDF | Visualizar/Abrir |
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