Por favor, use este identificador para citar o enlazar este ítem:
DOI: 10.14670/HH-11-847
Twittear
Registro completo de metadatos
Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Chen, Xinfeng | - |
dc.contributor.author | Wang, Liping | - |
dc.contributor.author | Yue, Dongli | - |
dc.contributor.author | Liu, Jinyan | - |
dc.contributor.author | Huang, Lan | - |
dc.contributor.author | Yang, Li | - |
dc.contributor.author | Cao, Ling | - |
dc.contributor.author | Qin, Guohui | - |
dc.contributor.author | Li, Anqi | - |
dc.contributor.author | Wang, Dan | - |
dc.contributor.author | Wang, Meng | - |
dc.contributor.author | Qi, Yu | - |
dc.contributor.author | Zhang, Bin | - |
dc.contributor.author | van der Bruggen, Pierre | - |
dc.contributor.author | Zhang, Yi | - |
dc.date.accessioned | 2022-02-28T08:44:32Z | - |
dc.date.available | 2022-02-28T08:44:32Z | - |
dc.date.issued | 2017 | - |
dc.identifier.citation | Histology and Histopathology, Vol.32, nº8, (2017) | es |
dc.identifier.issn | 1699-5848 | - |
dc.identifier.issn | 0213-3911 | - |
dc.identifier.uri | http://hdl.handle.net/10201/117428 | - |
dc.description.abstract | Antigens encoded by cancer-germline genes are attractive targets for cancer immunotherapy. In this study, we aimed to evaluate the mRNA expression of cancer-germline genes, expression of the encoded proteins in patients with esophageal squamous cell carcinoma (ESCC) and their correlations with clinical characteristics. In addition, the effects of downregulation cancer-germline genes on ESCC cells were assessed in vitro. Our results showed that cancer-germline genes were frequently expressed in ESCC samples. The positive rates of in ESCC samples were: 87% of MAGEA3, 60% of MAGE-A4, 65% of MAGE-C2, and 20% of NY-ESO-1 at mRNA level. MAGE-A3 expression was associated with age, lymph node metastasis and tumor stage (all P<0.05), while MAGE-C2 expression was only associated with tumor stage (P<0.05). Furthermore, the MAGE-A3 expressing patients had a poorer overall survival (P<0.05). Multivariate analysis identified MAGE-A3 as an independent poor prognostic marker in ESCC. In vitro assay, ESCC cell lines treated with specific siRNAs to down-regulate MAGE-A3 and MAGE-C2 resulted in decreased colony-formation and migration ability (P<0.05). Epithelial marker E-cadherin was up-regulated in siRNA-MAGE-A3/C2 cells compared to controls, whereas mesenchymal markers Vimentin, N-cadherin and Slug were downregulated (all P<0.05), suggesting a role for MAGE-A3/C2 in ESCC metastasis through inducing epithelial-mesenchymal transition. The present study revealed that cancergermline genes and their encoded proteins were frequently expressed in ESCC tumor samples and were related to poor prognosis. Thus, cancer-germline genes may serve as useful biomarkers and potential targets for ESCC patients | es |
dc.format | application/pdf | es |
dc.format.extent | 11 | es |
dc.language | eng | es |
dc.publisher | Universidad de Murcia. Departamento de Biología Celular e Histología | es |
dc.relation | Sin financiación externa a la Universidad | es |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Esophageal squamous cell carcinoma (ESCC) | es |
dc.subject | Cancer-germline genes | es |
dc.subject | Biomarkers | es |
dc.subject | Epithelialmesenchymal transition | es |
dc.subject.other | CDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología | es |
dc.title | Correlation between the high expression levels of cancer-germline genes with clinical characteristics in esophageal squamous cell carcinoma | es |
dc.type | info:eu-repo/semantics/article | es |
dc.identifier.doi | DOI: 10.14670/HH-11-847 | - |
Aparece en las colecciones: | Vol.32, nº8 (2017) |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
Chen-32-793-803-2017.pdf | 8,84 MB | Adobe PDF | Visualizar/Abrir |
Este ítem está sujeto a una licencia Creative Commons Licencia Creative Commons