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DOI 10.14670/HH-11-846
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Título: | Inflammatory mediators and signalling pathways controlling intervertebral disc degeneration |
Fecha de publicación: | 2017 |
Editorial: | Universidad de Murcia. Departamento de Biología Celular e Histología |
Cita bibliográfica: | Histology and Histopathology, Vol.32, nº6, (2017) |
ISSN: | 1699-5848 0213-3911 |
Materias relacionadas: | CDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología |
Palabras clave: | Intervertebral disc degeneration Inflammatory mediators Low back pain Neuroinflammation |
Resumen: | Intervertebral disc (IVD) degeneration (IDD) is one of the major causes of back pain, a condition that represents a serious socio-economic burden. Deeper knowledge of the complex and fine relationship between IVD degeneration, tissue inflammation and pain, appears to be critical to improve the current therapies, which have so far proven themselves ineffective. Upon degeneration, IVD tissues become inflamed, and this inflammatory microenvironment is associated with a cascade of degenerative events that may eventually cause discogenic pain. In particular, several studies have highlighted the major role of a number of proinflammatory mediators not only in the onset of the inflammatory condition, but also in the development of IDD in general. In this review, we will present the main pathological events that occur during disc degeneration, focusing on the relationship between the abnormal inflammatory milieu of the degenerating IVD, IDD and the generation of pain. Finally, we will present the current therapies for the treatment of IDD and low back pain, and the perspectives of future, more effective therapies. |
Autor/es principal/es: | Navone, Stefania Elena Marfia, Giovanni Giannoni, Amedeo Beretta, Matteo Guarnaccia, Laura Gualtierotti, Roberta Nicoli, Daniele Rampini, Paolo Campanella, Rolando |
URI: | http://hdl.handle.net/10201/117227 |
DOI: | DOI 10.14670/HH-11-846 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 20 |
Derechos: | info:eu-repo/semantics/openAccess Attribution-NonCommercial-NoDerivatives 4.0 Internacional |
Aparece en las colecciones: | Vol.32, nº6 (2017) |
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Fichero | Descripción | Tamaño | Formato | |
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Navone-32-523-542-2017.pdf | 349,25 kB | Adobe PDF | Visualizar/Abrir |
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