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DOI: 10.14670/HH-11-769
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Título: | Birth defects in juvenile Wistar rats after exposure to immunosuppressive drugs during pregnancy |
Fecha de publicación: | 2017 |
Editorial: | Universidad de Murcia. Departamento de Biología Celular e Histología |
Cita bibliográfica: | Histology and Histopathology, Vol.32, nº1, (2017) |
ISSN: | 1699-5848 0213-3911 |
Materias relacionadas: | CDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología |
Palabras clave: | Congenital malformation Rats Pregnancy Immunosuppressive Drugs Transplantation |
Resumen: | Introduction: Immunosuppressive drugs and their active metabolites can cross the placental barrier and enter fetal circulation. The adverse effects on the fetus include chromosomal aberrations, structural malformations, organ-specific toxicity and intrauterine growth retardation. The aim of our study was to investigate the impact of “safe” and “contraindicated” immunosuppressive drugs on birth defects in juvenile Wistar rats after exposure of pregnant female rats to these drugs. Material and methods: The study was conducted on 32 female Wistar rats, subjected to immunosuppressive regimens most commonly used in therapy of human kidney transplant recipients. The animals received drugs by oral gavage 2 weeks before pregnancy and during 3 weeks of pregnancy. Results: Treatment with mycophenolate mofetil and everolimus turned out to be toxic. We have noticed a significantly reduced number of live births in all pregnant rats exposed to these drugs in combination with calcineurin inhibitors and prednisone. Malformations and histological changes of fetal organs were confirmed after mycophenolate mofetil exposure during pregnancy. Conclusions: Mycophenolate mofetil turned out to be more toxic when used with tacrolimus than with cyclosporin (delivery of live offspring was possible only in the latter group). Everolimus in combination with cyclosporin effectively suppressed the fetal maturation in utero, but did not contribute to the development of malformations. |
Autor/es principal/es: | Kabat Koperska, Joanna Kolasa Wołosiuk, Agnieszka Pilutin, Anna Safranow, Krzysztof Kosik Bogacka, Danuta Baranowska Bosiacka, Irena Gołembiewska, Edyta Kędzierska, Karolina Domański, Leszek Ciechanowski, Kazimierz |
URI: | http://hdl.handle.net/10201/116670 |
DOI: | DOI: 10.14670/HH-11-769 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 13 |
Derechos: | info:eu-repo/semantics/openAccess Attribution-NonCommercial-NoDerivatives 4.0 Internacional |
Aparece en las colecciones: | Vol.32, nº1 (2017) |
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Kabat-Koperska-32-43-55-2017.pdf | 11,33 MB | Adobe PDF | Visualizar/Abrir |
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