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DOI: 10.14670/HH-11-730
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Título: | Aberrant levels of Wnt/β-catenin pathway components in a rat model of endometriosis |
Fecha de publicación: | 2016 |
Editorial: | Universidad de Murcia. Departamento de Biología Celular e Histología |
Cita bibliográfica: | Histology and Histopathology, Vol.31, nº8, (2016) |
ISSN: | 0213-3911 1699-5848 |
Materias relacionadas: | CDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología |
Palabras clave: | Endometriosis Wnt pathway β-catenin Galectin-3 Rat models |
Resumen: | Endometriosis is a benign gynecological disease affecting approximately 10-15% of women of reproductive age and 25-50% of all infertile women. It is characterized by the presence of glands and/or endometrial stroma outside the uterine cavity. Angiogenesis is a crucial process for the development and maintenance of endometriotic lesions. The Wnt/βcatenin pathway is a major promoter of angiogenesis in both physiological and pathological conditions. In the present study, we evaluated the expression of molecules related to the Wnt/β-catenin pathway in a rat model of peritoneal endometriosis. mRNA analyses showed significantly increased expression of Wnt4 and Wnt7b and decreased expression of Gsk3beta and E-cadherin in endometriotic lesions. However, there were no differences in β-catenin and Fzd2 mRNA expression. In addition, we observed a significant increase of nuclear β-catenin in endometriotic lesions, a hallmark of Wnt/ β -catenin pathway activation. Stromal β-catenin staining was found in 45.4% of endometrial tissues and 77.8% of endometriotic lesions. β-catenin nuclear localization was found in 18.2% of the endometrial tissues and 33.3% of endometriotic lesions. Finally, the expression of galectin-3, a regulator of this pathway, was increased in endometriosis. In summary, this pattern of Wnt/βcatenin components expression suggests an increased activity of this pathway in endometriosis. |
Autor/es principal/es: | Medina de Mattos, Rômulo Rodrigues Pereira, Paula Gouvêa de Oliveira Barros, Eliane Henriques da Silva, Julianna Yelimar Palmero, Celia Meireles da Costa, Nathália Ribeiro Pinto, Luis Felipe Rodrigues Pereira Gimba, Etel Hecht, Fábio Bueno Ferreira, Luciana Escorsim Machado, Daniel Leite de Oliveira, Felipe Eurico Nasciutti, Luiz |
URI: | http://hdl.handle.net/10201/113205 |
DOI: | DOI: 10.14670/HH-11-730 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 10 |
Derechos: | info:eu-repo/semantics/openAccess Attribution-NonCommercial-NoDerivatives 4.0 Internacional |
Aparece en las colecciones: | Vol.31, nº8 (2016) |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
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deMattos-31-933-942-2016.pdf | 8,85 MB | Adobe PDF | Visualizar/Abrir |
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