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DOI: 10.14670/HH-11-721
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Título: | Expression of tropomyosins in lung cancer - a potential role in carcinogenesis and its utility in a histopathological diagnosis |
Fecha de publicación: | 2016 |
Editorial: | Universidad de Murcia. Departamento de Biología Celular e Histología |
Cita bibliográfica: | Histology and Histopathology, Vol.31, nº8, (2016) |
ISSN: | 0213-3911 1699-5848 |
Materias relacionadas: | CDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología |
Palabras clave: | Tropomyosin Lung cancer Carcinogenesis Biomarkers |
Resumen: | We herein analyzed the relationships between tropomyosin protein expression levels and clinicopathological factors in order to determine the significance of tropomyosins in lung cancers. Although neoplastic cells expressed different isoforms of tropomyosin, overall expression levels were lower than those in bronchial and alveolar epithelial cells. In adenocarcinomas, tropomyosin levels were markedly reduced in poorly differentiated or solid subtype carcinomas, suggesting that a loss in the expression of tropomyosins is involved in the progression of lung adenocarcinomas. The potential utility of the immunohistochemical expression of tropomyosins for a histopathological diagnosis was also investigated. The sensitivity and specificity of a loss in the expression of tropomyosins were 100% and 50%, respectively, which were superior to those for the strong expression of p53 (sensitivity 100% and specificity 44%), a conventional biomarker. An immunohistochemical examination of tropomyosins may assist in the histopathological detection of lung cancer cells in small biopsy specimens. |
Autor/es principal/es: | Okudela, Koji Mitsui, Hideaki Woo, Tetsukan Kojima, Yoko Matsumura, Mai Arai, Hiromasa Suzuki, Takehisa Umeda, Shigeaki Saito, Yuichi Tajiri, Michihiko Masuda, Munetaka Kameda, Yoichi Ohashi, Kenichi |
URI: | http://hdl.handle.net/10201/113146 |
DOI: | DOI: 10.14670/HH-11-721 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 10 |
Derechos: | info:eu-repo/semantics/openAccess Attribution-NonCommercial-NoDerivatives 4.0 Internacional |
Aparece en las colecciones: | Vol.31, nº8 (2016) |
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Fichero | Descripción | Tamaño | Formato | |
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Okudela-31-857-866-2016.pdf | 7,44 MB | Adobe PDF | Visualizar/Abrir |
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