Por favor, use este identificador para citar o enlazar este ítem: DOI: 10.14670/HH-11-716

Título: Pore alterations of the endothelial lining of rat fenestrated intestinal capillaries exposed to acute stress
Fecha de publicación: 2016
Editorial: Universidad de Murcia. Departamento de Biología Celular e Histología
Cita bibliográfica: Histology and histopathology, Vol.31, nº7 (2016)
ISSN: 1699-5848
0213-3911
Materias relacionadas: CDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología
Palabras clave: Capillary pore
Fenestrated capillary
Stress
Interleukin-6
Intestine
Resumen: Stress-induced inflammatory responses in the portal system are characterized by elevations in serum concentrations of interleukin-6 (IL-6) and endotoxins such as lipopolysaccharides (LPS). LPS translocation from the intestinal to the capillary lumen occurs via LPS endocytosis by the capillary endothelium. Because the capillary endothelium of the small intestinal submucosa is fenestrated, we determined the role of pore modifications within the fenestrated endothelium in relaying inflammatory stress responses in the portal vein. We evaluated changes in the diameter and density of endothelial pores of the lamina propria of intestinal villi induced by continuous light (CL) exposure for 48 h and the correlation between these changes and serum IL-6 concentration in the portal vein in a rat model. We found significant increases in both the pore diameter and density, accompanied by a significant increase in portal IL-6 concentration; these changes were significantly attenuated by pretreatment with propranolol, a beta adrenergic receptor antagonist. In contrast, intravenous noradrenaline administration mimicked CL-induced modifications of the diameter and density of pores and the elevation of portal vein IL-6 concentration. These findings suggested that stress-induced inflammatory responses in the portal system may be a part of the modifications of the endothelial pores triggered by sympathetic activation.
Autor/es principal/es: Aosa, Taishi
Chiba, Seiichi
Kitamura, Hirokazu
Ina, Keisuke
Tatsukawa, Shuji
Moriwaki, Chinatsu
Wei, Huixing
Gotoh, Koro
Masaki, Takayuki
Kakuma, Tetsuya
Shibata, Hirotaka
Fujikura, Yoshihisa
URI: http://hdl.handle.net/10201/111441
DOI: DOI: 10.14670/HH-11-716
Tipo de documento: info:eu-repo/semantics/article
Número páginas / Extensión: 11
Derechos: info:eu-repo/semantics/openAccess
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
Aparece en las colecciones:Vol.31, nº7 (2016)

Ficheros en este ítem:
Fichero Descripción TamañoFormato 
Aosa-31-807-817-2016.pdf4,25 MBAdobe PDFVista previa
Visualizar/Abrir


Este ítem está sujeto a una licencia Creative Commons Licencia Creative Commons Creative Commons