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DOI: 10.14670/HH-11-746
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Título: | The low density lipoprotein receptor-related protein (LRP) 1 and its function in lung diseases |
Fecha de publicación: | 2016 |
Editorial: | Universidad de Murcia. Departamento de Biología Celular e Histología |
Cita bibliográfica: | Histology and histopathology, Vol.31, nº7 (2016) |
ISSN: | 1699-5848 0213-3911 |
Materias relacionadas: | CDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología |
Palabras clave: | Low density lipoprotein receptor-related protein 1 Extracellular matrix Proteases Lung |
Resumen: | The low density lipoprotein receptor-related protein (LRP) 1 is a ubiquitously expressed, versatile cell surface transmembrane receptor involved in embryonic development and adult tissue homeostasis. LRP1 binds and endocytoses a broad spectrum of over 40 ligands identified thus far, including lipoproteins, extracellular matrix proteins, proteases and protease/ inhibitor complexes and growth factors. Interactions with other membrane receptors and intracellular adaptors/scaffolding proteins allow LRP1 to modulate cell migration, survival, proliferation and (trans) differentiation. Because LRP1 displays a wide-range of interactions and activities, its expression and function is temporally and spatially tightly controlled. It is not, therefore, surprising that deregulation of LRP1 production and/or activity is observed in several diseases. In this review, we will systematically examine the evidence for the role of LRP1 in human pathologies placing special emphasis on LRP1-mediated pathogenesis of the lung. |
Autor/es principal/es: | Wujak, L. Markart, P. Wygrecka, M. |
URI: | http://hdl.handle.net/10201/111404 |
DOI: | DOI: 10.14670/HH-11-746 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 13 |
Derechos: | info:eu-repo/semantics/openAccess Attribution-NonCommercial-NoDerivatives 4.0 Internacional |
Aparece en las colecciones: | Vol.31, nº7 (2016) |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
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Wujak-31-733-745-2016.pdf | 3,36 MB | Adobe PDF | Visualizar/Abrir |
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