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DOI: 10.14670/HH-11-722
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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Kölbl, Alexandra C. | - |
dc.contributor.author | Jeschke, Udo | - |
dc.contributor.author | Friese, Klaus | - |
dc.contributor.author | Andergassen, Ulrich | - |
dc.date.accessioned | 2021-07-23T08:10:19Z | - |
dc.date.available | 2021-07-23T08:10:19Z | - |
dc.date.issued | 2016 | - |
dc.identifier.citation | Histology and histopathology: Vol.31, nº6 (2016) | es |
dc.identifier.issn | 1699-5848 | - |
dc.identifier.issn | 0213-3911 | - |
dc.identifier.uri | http://hdl.handle.net/10201/111281 | - |
dc.description.abstract | Almost 40 years ago, researchers found that the Thomsen-Friedenreich (TF) and the Thomsen nouvelle (Tn) antigens could be detected in carcinoma, but not in healthy tissue. A short time after that it became clear that TF and Tn are precursor molecules of the MN-blood group antigens. In normal tissue TF and Tn are coated by glycosyl structures, thereby forming the glycoproteins which are known to account for the MN-blood group antigens, but in malignant tissue these molecules are uncovered. TF, which has an additional Galectin-residue compared to Tn, is correlated with a more favourable prognosis for patients. On the contrary, patients with Tn-bearing tissues have a worse prognosis for overall and progression-free survival. It is known that TF and Tn are involved in the adhesion of tumour cells to the endothelium via a mechanism recruiting Galectin-3 and MUC-1, which is the first step in metastasis formation. Furthermore, it became clear that this pathway can be blocked by a growing number of molecules, thereby creating ways of therapeutical intervention. | es |
dc.format | application/pdf | es |
dc.format.extent | 9 | es |
dc.language | eng | es |
dc.publisher | Universidad de Murcia. Departamento de Biología Celular e Histología | es |
dc.relation | Sin financiación externa a la Universidad | es |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Antigen | es |
dc.subject | Breast Cancer | es |
dc.subject | Glycosyltransferase | es |
dc.subject | Metastasis | es |
dc.subject | Mucin | es |
dc.subject | Vaccination | es |
dc.subject.other | CDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología | es |
dc.title | The role of TF- and Tn-antigens in breast cancer metastasis | es |
dc.type | info:eu-repo/semantics/article | es |
dc.identifier.doi | DOI: 10.14670/HH-11-722 | - |
Aparece en las colecciones: | Vol.31, nº6 (2016) |
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Kolbl-31-613-621-2016.pdf | 165,63 kB | Adobe PDF | Visualizar/Abrir |
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