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DOI: 10.14670/HH-11-697
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Título: | Development of germ cell neoplasia in situ in chinchilla rabbits |
Fecha de publicación: | 2016 |
Editorial: | Universidad de Murcia. Departamento de Biología Celular e Histología |
Cita bibliográfica: | Histology and histopathology: Vol.31, nº5 (2016) |
ISSN: | 1699-5848 0213-3911 |
Materias relacionadas: | CDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología |
Palabras clave: | Germ cell neoplasia in situ POU5F1 c-kit Rabbit Animal model |
Resumen: | The present study was designed to describe the development of germ cell neoplasia in situ in Chinchilla rabbit by administration of estradiol. The study was performed in rabbits distributed into two groups: control and 17 β-estradiol. The determination of histological alterations and POU5F1 and c-kit proteins employed as biomarkers for the diagnosis of this neoplasia was carried out. Testicular descent and complete spermatogenesis were observed in the control group. The protein biomarkers were negative. However, in the rabbits treated with estradiol, the testes remained undescended with the gonocytes undifferentiated to spermatogonia. There were histological lesions owing to germ cell neoplasia in situ and positive to POU5F1 and c-kit proteins. These findings indicate that the chinchilla rabbit is an ideal model to study this neoplasia in which the histological characteristics and biomarkers of the disease could be clearly observed. Using this model we suggested that the persisting gonocytes could be responsible for the development of germ cell neoplasia in situ. |
Autor/es principal/es: | Vigueras-Villaseñor, Rosa María Montelongo Solís, Paola Chávez-Saldaña, Margarita Gutiérrez-Pérez, Oscar Cortés Trujillo, Lucero Rojas-Castañeda, Julio César |
URI: | http://hdl.handle.net/10201/110382 |
DOI: | DOI: 10.14670/HH-11-697 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 12 |
Derechos: | info:eu-repo/semantics/openAccess Attribution-NonCommercial-NoDerivatives 4.0 Internacional |
Aparece en las colecciones: | Vol.31, nº5 (2016) |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
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Vigueras-31-573-584-2016.pdf | 6,58 MB | Adobe PDF | Visualizar/Abrir |
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