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DOI: 10.14670/HH-11-688
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Título: | Myocardial Connexin-43 and N-Cadherin decrease during vanadium inhalation |
Fecha de publicación: | 2016 |
Editorial: | Universidad de Murcia. Departamento de Biología Celular e Histología |
Cita bibliográfica: | Histology and histopathology: Vol.31, nº4 (2016) |
ISSN: | 1699-5848 0213-3911 |
Materias relacionadas: | CDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología |
Palabras clave: | Air pollution Arrhythmias Connexin-43 N-cadherin Vanadium inhalation Clumping Myofibrils |
Resumen: | Particulate matter air pollution has considerably increased during the last decades; vanadium is a transition element adhered to this particulate matter, and the combustion of fossil fuels is the main source in the atmosphere. It has been reported that air pollution and specifically vanadium exposure increases the probability of suffering arrhythmias; however the biological mechanism of such a relationship remains unknown. It has been established that a diminished presence of NCadherin alters the Connexin-43 arrangement, and the consequent altered presence of these proteins predisposes to ventricular heart rate problems. We analyzed myocardial histology and the expression of N-Cadherin and Connexin-43 by immunohistochemistry in mouse that inhaled vanadium. Our results showed a significant and progressive reduction in both N-Cadherin and Connexin-43, as well as the presence of meganucleus; myofibrils disruption, and clumping in the exposed groups were also observed. Our findings add more information about a possible explanation for the arrythmogenic effect observed in dwellers of cities with high particulate matter atmospheric pollution. |
Autor/es principal/es: | Fortoul, Teresa I. Soto-Mota, Adrian Rojas-Lemus, Marcela Rodriguez-Lara, Vilaney GonzalezVillalva, Adriana Montaño, Luis F. Paez, Araceli Colin-Barenque, Laura López-Valdez, Nelly Cano Gutiérrez, Gumaro Bizarro-Nevares, Patricia Ustarroz-Cano, Martha |
URI: | http://hdl.handle.net/10201/109904 |
DOI: | DOI: 10.14670/HH-11-688 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 7 |
Derechos: | info:eu-repo/semantics/openAccess Attribution-NonCommercial-NoDerivatives 4.0 Internacional |
Aparece en las colecciones: | Vol.31, nº4 (2016) |
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Fichero | Descripción | Tamaño | Formato | |
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Fortoul-31-433-439-2016.pdf | 7,33 MB | Adobe PDF | Visualizar/Abrir |
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