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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Nam, Soo Jeong | - |
dc.contributor.author | Kim, Sehui | - |
dc.contributor.author | Kim, Ji Eun | - |
dc.contributor.author | Lim, Megan S. | - |
dc.contributor.author | Elenitoba-Johnson, Kojo S.J. | - |
dc.contributor.author | Kim, Chul Woo | - |
dc.contributor.author | Jeon, Yoon Kyung | - |
dc.date.accessioned | 2021-04-13T08:39:34Z | - |
dc.date.available | 2021-04-13T08:39:34Z | - |
dc.date.issued | 2016 | - |
dc.identifier.citation | Histology and Histopathology, vol.31, nº2, (2016) | es |
dc.identifier.issn | 1699-5848 | - |
dc.identifier.issn | 0213-3911 | - |
dc.identifier.uri | http://hdl.handle.net/10201/106383 | - |
dc.description.abstract | Background: Napsin A is commonly expressed in pulmonary adenocarcinomas and some renal cell carcinomas. However, napsin A expression in lymphoid neoplasms has never been reported. Methods: Glycoproteomic analyses of lymphoma-derived cell lines revealed napsin A expression in anaplastic large cell lymphoma (ALCL) cells. We thus investigated napsin A expression in lymphoid neoplasms. A variety of lymphomas (n=672) and histiocytic tumors (n=55) was immunostained for napsin A using patient tissues. Results: In reactive lymphoid tissues, only a few histiocytes were positive for napsin A. ALK-positive ALCLs most frequently expressed napsin A (34.4%, 11/32 cases) at a rate that was significantly higher compared with ALK-negative ALCL (8.6%, 3/35; P=0.015). Napsin A expression was also observed in 13.4% (20/149) of diffuse large B-cell lymphomas (DLBCL), 11.1% (15/134) of Hodgkin lymphomas, 4.9% (2/41) of follicular lymphomas, 6% (4/67) of peripheral T-cell lymphomas, and 3.8% (1/26) of plasma cell neoplasms. Otherwise, napsin A was not detected in any other types of lymphomas or histiocytic neoplasms. Napsin A expression in systemic ALCL was associated with a higher international prognostic index. ALCL and DLBCL patients with napsin A expression tended to have poor prognosis. Conclusion: These results demonstrated that napsin A is aberrantly expressed in a subset of lymphomas. The biological significance of napsin A in lymphomas warrants further study. | es |
dc.format | application/pdf | es |
dc.format.extent | 9 | es |
dc.language | eng | es |
dc.publisher | Universidad de Murcia. Departamento de Biología Celular e Histología | es |
dc.relation | Sin financiación externa a la Universidad | es |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Napsin A | es |
dc.subject | Lymphoma | es |
dc.subject | Anaplastic large cell lymphoma | es |
dc.subject | ALK | es |
dc.subject | Glycoproteomics | es |
dc.subject.other | CDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología | es |
dc.title | Aberrant expression of napsin A in a subset of malignant lymphomas | es |
dc.type | info:eu-repo/semantics/article | es |
dc.identifier.doi | 10.14670/HH-11-669 | - |
Aparece en las colecciones: | Vol.31, nº2 (2016) |
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Nam-31-213-221-2016.pdf | 5,39 MB | Adobe PDF | Visualizar/Abrir |
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