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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Swier, Vicki J. | - |
dc.contributor.author | Tang, Lin | - |
dc.contributor.author | Radwan, Mohamed M. | - |
dc.contributor.author | Hunter III, William J. | - |
dc.contributor.author | Agrawa, Devendra K. | - |
dc.date.accessioned | 2021-04-13T06:33:09Z | - |
dc.date.available | 2021-04-13T06:33:09Z | - |
dc.date.issued | 2016 | - |
dc.identifier.citation | Histology and Histopathology, vol.31, nº2, (2016) | es |
dc.identifier.issn | 1699-5848 | - |
dc.identifier.issn | 0213-3911 | - |
dc.identifier.uri | http://hdl.handle.net/10201/106342 | - |
dc.description.abstract | The effect of fructose in conjunction with high cholesterol diet in the development of atherosclerotic lesions in coronary arteries is not well established. Microswine were fed high cholesterol (HC) or a high cholesterol-high fructose (HCHF) diet containing 18-20% calories from fructose. All swine had high levels of serum cholesterol and non-HDL, thickened intima and accumulation of collagen in the coronaries. Swine fed with HC diet had less stenosis in coronary arteries, lower serum levels of non-HDL, triglycerides, cholesterol, and blood glucose than HCHF group. Coronary lesions in the HC swine were not as progressed as in HCHF and showed low LDL-expressed lipid-laden foam cells. The M1/M2 macrophage phenotype in the HCHF swine differed with the progression of atherosclerosis, with higher density of M1-phenotype in HCHF swine. There was high expression of CCR7 (M1-phenotype) in more advanced lesions in the fibrous cap-like areas, whereas M2- macrophages were abundant in the foam-cell cores. These findings suggest that the addition of a fructose to high cholesterol diet accelerates atherosclerotic lesions in coronary arteries with an increase in M1-macrophages and the propensity to develop features of metabolic syndrome. | es |
dc.format | application/pdf | es |
dc.format.extent | 10 | es |
dc.language | eng | es |
dc.publisher | Universidad de Murcia. Departamento de Biología Celular e Histología | es |
dc.relation | Sin financiación externa a la Universidad | es |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Atherosclerosis | es |
dc.subject | Coronary plaques | es |
dc.subject | Fructose diet | es |
dc.subject | Macrophages | es |
dc.subject | Metabolic syndrome | es |
dc.subject.other | CDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología | es |
dc.title | The role of high cholesterol-high fructose diet on coronary arteriosclerosis | es |
dc.type | info:eu-repo/semantics/article | es |
dc.identifier.doi | 10.1470/HH-11-652 | - |
Aparece en las colecciones: | Vol.31, nº2 (2016) |
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Fichero | Descripción | Tamaño | Formato | |
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Swier-31-167-176-2016.pdf | 16,4 MB | Adobe PDF | Visualizar/Abrir |
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