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dc.contributor.authorGimeno, L-
dc.contributor.authorMartínez-Banaclocha, H-
dc.contributor.authorBernardo, MV-
dc.contributor.authorBolarin, JM-
dc.contributor.authorMarín, L-
dc.contributor.authorLópez-Hernández, R-
dc.contributor.authorLópez-Alvarez, MR-
dc.contributor.authorMoya-Quiles, MR-
dc.contributor.authorMuro, M-
dc.contributor.authorFrias-Iniesta, JF-
dc.contributor.authorMartínez-Escribano, J-
dc.contributor.authorAlvarez-López, MR-
dc.contributor.authorMinguela, A-
dc.contributor.authorCampillo, JA-
dc.date.accessioned2021-03-24T16:36:42Z-
dc.date.available2021-03-24T16:36:42Z-
dc.date.issued2019-03-28-
dc.identifier.citationCancers (Basel). 2019 Mar 28;11(4):438es
dc.identifier.urihttp://hdl.handle.net/10201/105592-
dc.description.abstractBackground: Natural killer (NK) and CD8+ T cells are involved in the immune response against melanoma. C-Type lectin-like NK cell receptors are located in the Natural Killer Complex (NKC) region 12p13.2-p12.3 and play a critical role in regulating the activity of NK and CD8+ T cells. An association between polymorphisms in the NKC region, including the NKG2D gene and NKG2A promoter, and the risk of cancer has been previously described. The aim of this study was to analyze the association of polymorphisms in the NKC region with cutaneous melanoma in patients from southeastern Spain. Methods: Seven single-nucleotide polymorphisms (SNPs) in the NKG2D gene (NKC3,4,7,9,10,11,12), and one SNP in the NKG2A promoter (NKC17) were genotyped by a TaqMan 5' Nuclease Assay in 233 melanoma patients and 200 matched healthy controls. Results: A linkage disequilibrium analysis of the SNPs performed in the NKC region revealed two blocks of haplotypes (Hb-1 and Hb-2) with 14 and seven different haplotype subtypes, respectively. The third most frequent haplotype from the block Hb-2-NK3 (CAT haplotype)-was significantly more frequent on melanoma patients than on healthy controls (p = 0.00009, Pc = 0.0006). No further associations were found when NKC SNPs were considered independently. Conclusions: Our results suggest an association between NKG2D polymorphisms and the risk of cutaneous malignant melanoma. Keywords: Melanoma; NK cell; NKG2A; NKG2D; gene polymorphism.es
dc.formatapplication/pdfes
dc.format.extent13es
dc.languageenges
dc.publisherMDPIes
dc.relationÁmbito del proyecto (Europeo, nacional o regional): Nacional Agencia/entidad financiadora: ISCIII Convocatoria: FIS-ISCIII Nombre del proyecto: Mecanismos de Inmunoterapia en cáncer de piel tipo Melanoma Cutáneo Código: 11/1926es
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectMelanomaes
dc.subjectNK celles
dc.subjectNKG2Aes
dc.subjectNKG2Des
dc.subjectgene polymorphismes
dc.titleNKG2D Polymorphism in Melanoma Patients from Southeastern Spaines
dc.typeinfo:eu-repo/semantics/articlees
dc.relation.publisherversionhttps://www.mdpi.com/2072-6694/11/4/438es
dc.identifier.doi10.3390/cancers11040438-
dc.contributor.departmentAnatomía Humana y Psicobiología-
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