Por favor, use este identificador para citar o enlazar este ítem:
10.3389/fcell.2020.588851
Twittear
Registro completo de metadatos
Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | García-Guillén, Isabel M. | - |
dc.contributor.author | Alonso, Antonia | - |
dc.contributor.author | Morales-Delgado, Nicanor | - |
dc.contributor.author | Andrés, Belén | - |
dc.contributor.author | Puelles López, Luis | - |
dc.contributor.author | López-Bendito, Guillermina | - |
dc.contributor.author | Marín, Faustino | - |
dc.contributor.author | Aroca Tejedor, Pilar | - |
dc.contributor.other | Facultades, Departamentos, Servicios y Escuelas::Departamentos de la UMU::Anatomía Humana y Psicobiología | es |
dc.date.accessioned | 2021-03-24T07:54:36Z | - |
dc.date.available | 2021-03-24T07:54:36Z | - |
dc.date.created | 2020 | - |
dc.date.issued | 2020-10-20 | - |
dc.identifier.citation | Frontiers in Cell and Developmental Biology, 2020 8:588851 Front. Cell Dev. Biol.. | es |
dc.identifier.issn | 2296-634X | - |
dc.identifier.uri | http://hdl.handle.net/10201/105581 | - |
dc.description | © 2020. The authors. This document is made available under the CC-BY 4.0 license http://creativecommons.org/licenses/by /4.0/ This document is the Published version of a Published Work that appeared in final form in Frontiers in Cell and Developmental Biology. To access the final edited and published work see https://doi.org/10.3389/fcell.2020.588851 | - |
dc.description.abstract | The interpeduncular nucleus (IPN) is a hindbrain structure formed by three main subdivisions, the prodromal (Pro) domain located at the isthmus (Ist), and the rostral and caudal interpeduncular domains (IPR, IPC) within rhombomere 1 (r1). Various cell populations can be detected in the IPN through the expression of the Nkx6.1, Otp, Otx2, Pax7, and/or Irx2 transcription factors. These cell populations follow independent dorsoventral tangential and radial migratory routes targeting the ventral paramedian region of Ist and r1. Here we set out to examine the influence of the Netrin-1/DCC pathway on these migrations, since it is known to regulate other processes of neuronal migration in the brain. To this end, we analyzed IPN development in late gestational wild-type and DCC-/- mice, using mainly in situ hybridization (ISH) to identify the cells expressing each of the aforementioned genes. We found that the migration of Nkx6.1 + and Irx2 + cells into the Pro domain was strongly disrupted by the loss of DCC, as occurred with the migration of Pax7 +, Irx2 +, and Otp + cells that would normally form the IPR. In addition, there was mild impairment of the migration of the Pax7 + and Otx2 + cells that form the IPC. These results demonstrate that the Netrin-1/DCC signaling pathway is involved in the migration of most of the IPN populations, mainly affecting those of the Pro and IPR domains of this nucleus. There are psychiatric disorders that involve the medial habenula (mHb)-IPN system, so that this experimental model could provide a basis to study their neurodevelopmental etiology. | es |
dc.format | application/pdf | es |
dc.format.extent | 11 | es |
dc.language | eng | es |
dc.publisher | Frontiers Media | - |
dc.relation | This work was funded by the Seneca Foundation to LP(Autonomous Community of Murcia, Excellency Researchcontract, reference: 19904/GERM/15; 5672 Fundación Séneca;project name: Genoarchitectonic Brain Development andApplications to Neurodegenerative Diseases and Cancer)and by the Knowledge Generation Program of the SpanishGovernment to GL-B (PGC2018-096631-B-I00). IG-G wasrecipient of a predoctoral fellowship of the FPU program fromthe University of Murcia. | es |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights | Atribución 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | IPN | es |
dc.subject | Interpeduncular nucleus | es |
dc.subject | Prodromal | es |
dc.subject | Interpeduncular rostral | es |
dc.subject | Interpeduncular caudal | es |
dc.subject | Isthmus | es |
dc.subject | Rrhombomere 1 | es |
dc.subject | Medial habenula | es |
dc.subject | Rhombomere 2 | es |
dc.subject | Rhombomere 1 rostral | es |
dc.subject | Rhombomere 1 caudal | es |
dc.subject.other | CDU::5 - Ciencias puras y naturales | es |
dc.title | Netrin-1/DCC signaling differentially regulates the migration of Pax7, Nkx6.1, Irx2, Otp and Otx2 cell populations in the developing interpeduncular nucleus | es |
dc.type | info:eu-repo/semantics/article | es |
dc.relation.publisherversion | https://www.frontiersin.org/articles/10.3389/fcell.2020.588851/full | es |
dc.identifier.doi | 10.3389/fcell.2020.588851 | - |
Aparece en las colecciones: | Artículos: Anatomía Humana y Psicobiología |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
García-Guillen et al-2020.pdf | 5,47 MB | Adobe PDF | Visualizar/Abrir |
Este ítem está sujeto a una licencia Creative Commons Licencia Creative Commons