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10.14670/HH-11-646
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Título: | Development and preclinical evaluation of a new galactomannan-based dressing with antioxidant properties for wound healing |
Fecha de publicación: | 2015 |
Editorial: | Universidad de Murcia. Departamento de Biología Celular e Histología |
Cita bibliográfica: | Histology and Histopathology, vol. 30, nº 12, (2015) |
ISSN: | 1699-5848 0213-3911 |
Materias relacionadas: | CDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología |
Palabras clave: | Galactomanan-based matrix Antioxidant wound dressing Skin wound healing Oxidative stress |
Resumen: | We describe a novel wound dressing (HR006) with two components: a lyophilized matrix of the galactomannan from locust bean gum (LBG) and an antioxidant hydration solution (AHsol ) containing curcumin and N-acetyl-L-cysteine (NAC). Physicostructural analyses of the LBG matrix revealed homogeneous interconnected pores with high absorbing capacity showing excellent properties for moist wound care (MWC). In an in vitro oxidative stress fibroblast injury model, the AHsol showed relevant protective effects reducing intracellular reactive oxygen species (ROS) production, rescuing cell viability, and regulating expression of inflammation-related genes (COX-2, TNFα, IL-1α, IL-1β). The new dressing showed good biocompatibility profile as demonstrated by cytotoxicity, hemocompatibility, and skin irritation tests. Moreover, in an in vivo skin wound model in pigs, this dressing enhanced the production of healthy and organized granulation tissue and re-epithelization. In summary, HR006 exhibits significant antioxidant activity, good biocompatibility, and excellent repair capabilities improving tissue remodeling and the healing of wounds. |
Autor/es principal/es: | Castro, Begoña Palomares, Teodoro Azcoitia, Iker Bastida, Felix del Olmo, Maite Soldevilla, Javier J. Alonso-Varona, Ana |
URI: | http://hdl.handle.net/10201/103662 |
DOI: | 10.14670/HH-11-646 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 14 |
Derechos: | info:eu-repo/semantics/openAccess Atribución-NoComercial-SinDerivadas 3.0 España |
Aparece en las colecciones: | Vol.30,nº12 (2015) |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
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Castro-30-1499-1512-2015.pdf | 22,62 MB | Adobe PDF | Visualizar/Abrir |
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