Por favor, use este identificador para citar o enlazar este ítem: https://doi.org/10.1007/s10522-018-9778-0

Título: Age-related changes in mitochondrial membrane composition of Nothobranchius furzeri. Comparison with a longer-living Nothobranchius species
Fecha de publicación: 15-feb-2019
Editorial: Springer Nature
Cita bibliográfica: Biogerontology. 20(1):83-92, 2019
ISSN: 13895729
Materias relacionadas: CDU::5 - Ciencias puras y naturales
Palabras clave: Aging
Resumen: Membrane compositions, particularly of mitochondria, could be critical factors in the mechanisms of growth and aging, especially during phases of high oxidative stress that result in molecular damage. Changes affecting lipid class or fatty acid (FA) compositions could affect phospholipid (PL) properties and alter mitochondrial function. In the present study, mitochondrial membrane PL compositions were analysed throughout the life-cycle of Nothobranchius furzeri, a species with explosive growth and one of the shortest-lived vertebrates. Mitochondrial PLs showed several changes with age. Proportions of total PLs and PC were reduced while an increase in PS, CL and PE was observed, mainly between the 2.5 and 5 months of fish age, the time during which animals doubled their weight. FA compositions of individual PLs in mitochondria were also significantly affected with age suggesting the existence of increasing damage to mitochondrial lipids during the life- cycle of N. furzeri that could be one of the main contributors to degraded mitochondrial function associated with aging. The peroxidation index values from N. furzeri mitochondrial PLs were significantly lower than those reported in N. rachovii, a species with a 2-fold longer life span than N. furzeri, which seems to contradict the membrane pacemaker theory of animal metabolism
Autor/es principal/es: Almaida Pagán, Pedro Francisco
Ortega-Sabater C.
Lucas-Sanchez A.
Gonzalez-Silvera D.
Martinez-Nicolas A.
Rol de Lama, María de los Ángeles
Mendiola P.
de Costa J.
Facultad/Departamentos/Servicios: Facultades, Departamentos, Servicios y Escuelas::Departamentos de la UMU::Fisiología
Versión del editor: https://link.springer.com/article/10.1007%2Fs10522-018-9778-0
URI: http://hdl.handle.net/10201/103104
DOI: https://doi.org/10.1007/s10522-018-9778-0
Tipo de documento: info:eu-repo/semantics/article
Número páginas / Extensión: 27
Derechos: info:eu-repo/semantics/openAccess
Atribución-NoComercial-SinDerivadas 3.0 España
Aparece en las colecciones:Artículos: Fisiología

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