Por favor, use este identificador para citar o enlazar este ítem:
10.1016/j.sbi.2019.01.020
Twittear
Título: | B12-based photoreceptors: from structure and function to applications in optogenetics and synthetic biology |
Fecha de publicación: | ago-2019 |
Cita bibliográfica: | Current Opinion in Structural Biology 2019, 57:47-55 |
ISSN: | 0959-440X |
Palabras clave: | CarH Light Optogenetics Cobalamin Photochemistry Synthetic biology Photoregulation |
Resumen: | Vitamin B12-based photoreceptor proteins sense ultraviolet (UV), blue or green light using 5´-deoxyadenosylcobalamin (AdoCbl). The prototype of this widespread bacterial photoreceptor family, CarH, controls light-dependent gene expression in photoprotective cellular responses. It represses transcription in the dark by binding to operator DNA as an AdoCbl-bound tetramer, whose disruption by light relieves operator binding to allow transcription. Structures of the "dark" (free and DNA-bound) and "light" CarH states and studies on the unusual AdoCbl photochemistry have provided fundamental insights into these photoreceptors. We highlight these, the plasticity within a conserved mode of action among CarH homologs, their distribution, and their promising applications in optogenetics and synthetic biology. |
Autor/es principal/es: | Padmanabhan, S Pérez-Castaño, Ricardo Elías Arnanz, Montserrat |
Facultad/Departamentos/Servicios: | Facultades, Departamentos, Servicios y Escuelas::Departamentos de la UMU::Genética y Microbiología |
URI: | http://hdl.handle.net/10201/103089 |
DOI: | 10.1016/j.sbi.2019.01.020 |
Tipo de documento: | info:eu-repo/semantics/article |
Derechos: | info:eu-repo/semantics/openAccess Atribución-NoComercial-SinDerivadas 3.0 España |
Aparece en las colecciones: | Artículos: Genética y Microbiología |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
Curr Opin Struc Biol 2019.pdf | 3,74 MB | Adobe PDF | Visualizar/Abrir |
Este ítem está sujeto a una licencia Creative Commons Licencia Creative Commons