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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Garaulet Aza, Marta | - |
dc.contributor.other | Facultades, Departamentos, Servicios y Escuelas::Departamentos de la UMU::Fisiología | es |
dc.date.accessioned | 2021-02-11T12:46:18Z | - |
dc.date.available | 2021-02-11T12:46:18Z | - |
dc.date.issued | 2020 | - |
dc.identifier.uri | http://hdl.handle.net/10201/103057 | - |
dc.description.abstract | Night shift work, behavioral rhythms, and the common MTNR1B risk single nucleotide polymorphism (SNP), rs10830963, associate with type 2 diabetes, however, whether they exert joint effects to exacerbate type 2 diabetes risk is unknown. Among employed participants of European ancestry in the UK Biobank (N=189,488), we aimed to test the cross-sectional independent associations and joint interactions of these risk factors on odds of type 2 diabetes (n=5,042 cases) and HbA1c levels (n=175,156). Current shift work, definite morning or evening preference, and MTNR1B rs10830963 risk-allele associate with type 2 diabetes and HbA1c levels. The effect of rs10830963 was not modified by shift work schedules. While marginal evidence of interaction between selfreported morningness-eveningness preference and rs10830963 was seen on risk of type 2 diabetes, this interaction did not persist when analysis was expanded to include all participants regardless of employment status and when using accelerometer-derived sleep-midpoint as an objective measure of morningness-eveningness preference. Our findings suggest that the MTNR1B risk-allele carriers may not have greater vulnerability to shift work or morningness-eveningness preference. | es |
dc.format | application/pdf | es |
dc.format.extent | 41 | es |
dc.language | eng | es |
dc.relation | Sociedad Española para el estudio de la Obesidad y el Ministerio de investigación, desarrollo e innovación, España es un país de cenadores tardíos ¿ un habito asociado a riesgo metabólico? (desde la observación, a través del mecanismo y hacia la intervención, SAF2017-84135-R | es |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.rights | Atribución-NoComercial-SinDerivadas 3.0 España | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ | * |
dc.title | Assessment of MTNR1B type 2 diabetes genetic risk modification by shift work and morningness-eveningness preference in the UK Biobank | es |
dc.title.alternative | MTNR1B type 2 diabetes genetic risk, shift work, and morningnesseveningness preference | es |
dc.type | info:eu-repo/semantics/article | es |
Aparece en las colecciones: | Artículos: Fisiología |
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db19-0606.pdf | 309,66 kB | Adobe PDF | Visualizar/Abrir |
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