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10.14670/HH-11-64510.14670/HH-11-645
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Título: | Ovarian serous carcinogenesis from tubal secretory cells |
Fecha de publicación: | 2015 |
Editorial: | Universidad de Murcia. Departamento de Biología Celular e Histología |
Cita bibliográfica: | Histology and Histopathology, vol. 30, nº 11, (2015) |
ISSN: | 1699-5848 0213-3911 |
Materias relacionadas: | CDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología |
Palabras clave: | Ovarian serous carcinoma Secretory cell Fallopian tube LGSC HGSC |
Resumen: | Due to a poor understanding of tumorigenesis, ovarian cancers remain the most lethal gynecologic malignancy and cause horrific deaths. In the last decade, a new dualistic model for ovarian cancer was proposed, wherein ovarian serous cancers are classified as either high-grade or low-grade, with each having different tumorigenic processes, and pathologic and clinical features. Surprisingly, both high- and lowgrade ovarian serous cancers were recently found to originate not in the ovaries, but rather from the secretory cells of the fallopian tube, mostly from the tubal fimbriated ends. In this article, we review the evidentiary basis for the aforementioned paradigm shift in the cell origin of ovarian serous cancers, as well as its potential clinical implications |
Autor/es principal/es: | Zhang, Wenjing Wei, Linxuan Li, Lingmin Yang, Binlie Kong, Beihua Yao, Guang Zheng, Wenxin |
URI: | http://hdl.handle.net/10201/103021 |
DOI: | 10.14670/HH-11-64510.14670/HH-11-645 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 8 |
Derechos: | info:eu-repo/semantics/openAccess Atribución-NoComercial-SinDerivadas 3.0 España |
Matería geográfica: | , , |
Aparece en las colecciones: | Vol.30,nº11 (2015) |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
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Zhang-30-1295-1302-2015.pdf | 7,96 MB | Adobe PDF | Visualizar/Abrir |
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