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http://dx.doi.org/10.1016/j.abb.2015.08.020
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Título: | Blue Copper Proteins: A rigid machine for efficient electron transfer, a flexible device for metal uptake |
Fecha de publicación: | 31-ago-2015 |
Fecha de defensa / creación: | 24-ago-2015 |
Cita bibliográfica: | Archives of Biochemistry and Biophysics, 584, 2015, 134-148 |
ISSN: | 0003-9861 |
Materias relacionadas: | CDU::5 - Ciencias puras y naturales::54 - Química::546 - Química inorgánica CDU::5 - Ciencias puras y naturales::57 - Biología::577 - Bioquímica. Biología molecular. Biofísica |
Palabras clave: | Blue copper proteins azurin rusticyanin rack/entatic cancer therapy |
Resumen: | Blue copper proteins (BCPs) are small and generally soluble copper-containing proteins which participate in monoelectron transfer processes in biological systems. An overview of their electronic and tertiary structure is detailed here. The well-established entatic/rack-induced mechanism is explained by comparing thermodynamic parameters between the folded (tense) and the unfolded (relaxed) forms of the BCP rusticyanin. Recently, NMR solution data have shown that the active sites of BCPs in absence of the metal ion, i.e. in the apoforms, are flexible in the micro-to-second timescale. The rigidity proposed by the entatic/rack-induced mechanism is an imperative for the holoprotein to perform electron transfer; while the flexibility of the apocupredoxin is necessary to uptake the metal ion from the metallochaperones. These apparently contradictory requirements are discussed in the present work. Finally, the role of azurin and some peptides derived from it in anticancer therapy are also described. |
Autor/es principal/es: | Pérez-Henarejos, Sergio Alejo Alcaraz, Luis Antonio Donaire González, Antonio |
Facultad/Departamentos/Servicios: | Departamento de Química Inorgánica Facultad de Química |
Versión del editor: | https://www.sciencedirect.com/science/article/pii/S0003986115300461?via%3Dihub |
URI: | http://hdl.handle.net/10201/101944 |
DOI: | http://dx.doi.org/10.1016/j.abb.2015.08.020 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 46 |
Derechos: | info:eu-repo/semantics/openAccess Atribución-NoComercial-SinDerivadas 3.0 España |
Aparece en las colecciones: | Artículos: Química Inorgánica |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
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ABB_2015_BCPs.pdf | Blue Copper Proteins: A Rigid Machine for Efficient Electron Transfer, a Flexible Device for Metal Uptake | 790,53 kB | Adobe PDF | Visualizar/Abrir |
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