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Título: | Tumor-associated fibroblasts (Part I): active stromal participants in tumor development and progression? |
Fecha de publicación: | 2002 |
Editorial: | Murcia: F. Hernández |
Cita bibliográfica: | Histology and histopathology, Vol. 17, nº 2 (2002) |
ISSN: | 1699-5848 0213-3911 |
Materias relacionadas: | CDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología |
Palabras clave: | Desmoplasia Myofibroblast |
Resumen: | Phenotypic and functional characteristics of tumor associated fibroblasts (TAF) in contrast to normal fibroblasts are re v i e wed in this first synopsis (part I). Terms as tumor stroma, desmo-plasia, T A F , myofibroblast, and fetal-type fibroblast are defined, and experimental systems to study heterologous cell interactions are presented. While we only start to gather information on the genotype of T A F , a broad range of data deals with the e xpression profile of these cells, co v ering e.g. ECM and ECM-modulating molecules, growth factors and cytokines. Summarizing the recent state of kno w l e d g e indicates that TAF provide sources for tumor diagnosis and therap y , that ha v e to be further defined in an or g an- s p e c i f ic approach in terms of the functional impact on the tumor cell and its environment (see part II). |
Autor/es principal/es: | Kunz-Schughart, L.A. Knuechel, R. |
URI: | http://hdl.handle.net/10201/52091 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 23 |
Derechos: | info:eu-repo/semantics/openAccess |
Aparece en las colecciones: | Vol.17, nº 2 (2002) |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
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Kunz-17-599-621-2002.pdf | 2,41 MB | Adobe PDF | Visualizar/Abrir |
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