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Título: | Tumor suppression by p53, making cells senescent |
Fecha de publicación: | 2010 |
Editorial: | Murcia : F. Hernández |
ISSN: | 0213-3911 |
Materias relacionadas: | 616 - Patología. Medicina clínica. Oncología |
Palabras clave: | Cellular senescence Tumor suppression |
Resumen: | Cellular senescence is a permanent cell cycle arrest and a potent tumor suppression mechanism. The p53 tumor suppressor is a sequence-specific transcription factor and acts as a central hub sensing various stress signals and activating an array of target genes to induce cell cycle arrest, apoptosis, and senescence. Recent reports showed that restoration of p53 induces premature senescence and tumor regression in mice with hepatocarcinomas or sarcomas. Thus, p53- mediated senescence is capable of eliminating cancer cells in vivo. p63 and p73, two homologues of p53, have similar function in cell cycle arrest and apoptosis. However, the role of p63 and p73 in cellular senescence is elusive. In this review, we will discuss how p53 regulates senescence and future studies about p53 family members in senescence. |
Autor/es principal/es: | Qian, Yingjuan Chen, X. |
Forma parte de: | Histology and histopathology |
URI: | http://hdl.handle.net/10201/42611 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 12 |
Derechos: | info:eu-repo/semantics/openAccess |
Aparece en las colecciones: | Vol.25, nº4 (2010) |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
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Tumor suppression by p53 making cells senescent.pdf | 322,24 kB | Adobe PDF | Visualizar/Abrir |
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