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Título: | Distribution of immunoreactive transforming growth factor-alpha in non-neoplastic human salivary glands |
Fecha de publicación: | 1995 |
Editorial: | Murcia : F. Hernández |
ISSN: | 0213-3911 |
Materias relacionadas: | CDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología::616.3 - Patología del aparato digestivo. Odontología |
Palabras clave: | Salivary gland Inmunocytochemistry |
Resumen: | The distribution of immunoreactive transforming growth factor-alpha (TGF-a) was studied in non-neoplastic human major and minor salivary glands using an immunoperoxidase assay in conjuction with an antiserum to human TGF-a. The ductal cell components of all major and minor salivary glands were found to contain significant amounts of TGF-a immunoreactivity. In contrast, acinar and myoepithelial cells consistently lacked immune reaction product in both types of glands. Occasionally, an asynchronous pattern of TGF-a ductal cell immunoreactivity was observed in specific ducts within a section. Also, intraductal secretions, when present, were found to contain TGF-a immunoreactive material. Ductal cells and connective tissue from salivary glands samples showing significant lymphocytic infiltration and loss of acinar cells exhibited higher levels of TGF-a immunoreactivity than normal salivary gland samples. These observations demonstrate, for the first time, the presence of TGF-a immunoreactivity in specific structural components of non-neoplastic human major and minor salivary glands. It will be important in future studies to determine whether alterations in TGF-a expression are detectable in diverse types of salivary gland tumors. |
Autor/es principal/es: | Ogbureke, K.U.E. MacDaiel, R.K. Jacob, R.S. Durban, E.M. |
Forma parte de: | Histology and histopathology |
URI: | http://hdl.handle.net/10201/18747 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 6 |
Derechos: | info:eu-repo/semantics/openAccess |
Aparece en las colecciones: | Vol.10, nº 3 (1995) |
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Fichero | Descripción | Tamaño | Formato | |
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Distribution of immunoreactive transforming growth factoralpha in nonneoplastic human salivary glands.pdf | 3,39 MB | Adobe PDF | Visualizar/Abrir |
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