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https://doi.org/10.14670/HH-18-724
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Título: | Myxoid pleomorphic liposarcoma |
Fecha de publicación: | 2024 |
Editorial: | Universidad de Murcia, Departamento de Biologia Celular e Histiologia |
Cita bibliográfica: | Histology and Histopathology Vol. 39, nº9 (2024) |
ISSN: | 0213-3911 1699-5848 |
Materias relacionadas: | CDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología |
Palabras clave: | Myxoid pleomorphic liposarcoma (MPL) Pleomorphic liposarcoma (PL) Myxoid liposarcoma (ML) Dedifferentiated liposarcoma (DDLP) Atypical spindle cell/pleomorphic lipomatous tumor (ASPLT) Retinoblastoma 1 (RB1) MDM2 CDK4 |
Resumen: | Myxoid pleomorphic liposarcoma (MPL) is an extremely rare adipocytic tumor, recently recognized as a distinct entity in the 5th edition of the World Health Organization (WHO) Classification of Soft Tissue and Bone Tumors. Predominantly found in the mediastinum of young women, MPLs exhibit a combination of histological features characteristic of myxoid liposarcoma and pleomorphic (lipo)sarcoma. Their unique molecular features distinguish MPLs from other liposarcomas. Unlike myxoid liposarcomas and well-differentiated/dedifferentiated liposarcomas, MPLs lack specific FUS/EWSR1::DDIT3 gene fusions and MDM2/CDK4 gene amplifications, respectively. MPLs are associated with complex karyotypes, further highlighting their distinct genetic profile. They demonstrate aggressive growth patterns, high recurrence rates, and a high tendency to metastasize. These factors contribute to a poor prognosis, with a median survival of approximately 22.6 months. The aim of this review article is to provide a comprehensive summary of previously documented case reports and studies related to MPLs. By shedding light on the intricate details of MPLs, researchers and clinicians can gain valuable insights that may pave the way for improvements in diagnosis, treatment, and patient outcomes in the future. |
Autor/es principal/es: | Fadaei, Sharareh Cordier, Fleur Ferdinande, Liesbeth Dorpe, Jo Van Creytens, David |
URI: | http://hdl.handle.net/10201/143599 |
DOI: | https://doi.org/10.14670/HH-18-724 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 8 |
Derechos: | info:eu-repo/semantics/openAccess Attribution-NonCommercial-NoDerivatives 4.0 Internacional |
Aparece en las colecciones: | Vol.39, nº9 (2024) |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
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Fadaei-39-1101-1108-2024.pdf | 1,01 MB | Adobe PDF | Visualizar/Abrir |
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