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Título: Durability of bioprosthetic aortic valve replacement in patients under the age of 60 years — 1-year follow-up from the prospective INDURE registry
Fecha de publicación: 18-jul-2023
Editorial: Oxford University Press
Cita bibliográfica: Interdisciplinary CardioVascular and Thoracic Surgery 2023, 37(4), ivad115
ISSN: 2753-670X
Palabras clave: Surgical aortic valve replacement
Structural valve degeneration
Valve durability
Resumen: OBJECTIVES: We report 1-year safety and clinical outcomes in patients <60 years undergoing bioprosthetic surgical aortic valve intervention. METHODS: The INSPIRIS RESILIA Durability Registry is a prospective, multicentre registry to assess clinical outcomes of patients <60 years. Patients with planned SAVR with or without concomitant replacement of the ascending aorta and/or coronary bypass surgery were included. Time-related valve safety, haemodynamic performance and quality of life (QoL) at 1 year were assessed. RESULTS: A total of 421 patients were documented with a mean age of 53.5 years, 76.5% being male and 27.2% in NYHA class III/IV. Outcomes within 30 days included cardiovascular-related mortality (0.7%), time-related valve safety (VARC-2; 5.8%), thromboembolic events (1.7%), valve-related life-threatening bleeding (VARC-2; 4.3%) and permanent pacemaker implantation (3.8%). QoL was significantly increased at 6 months and sustained at 1 year. Freedom from all-cause mortality at 1 year was 98.3% (95% confidence interval 97.1; 99.6) and 81.8% were NYHA I versus 21.9% at baseline. No patient developed structural valve deterioration stage 3 (VARC-3). The mean aortic pressure gradient was 12.6 mmHg at 1 year and the effective orifice area was 1.9 cm2. CONCLUSIONS: The 1-year data from the INSPIRIS RESILIA valve demonstrate good safety and excellent haemodynamic performance as well as an early QoL improvement.
Autor/es principal/es: Meuris, Bart
Roussel, Jean-Christian
Borger, Michael A.
Siepe, Matthias
Stefano, Pierluigi
Laufer, Günther
Langanay, Thierry
Theron, Alexis
Grabenwöger, Martin
Binder, Konrad
Demers, Philippe
Pesotto, Renzo
Leeuwen, Wouter van
Bourguignon, Thierry
Cánovas López, Sergio
Mariscalco, Giovanni
Coscioni, Enrico
Dagenais, Francois
Wendler, Olaf
Polvani, Gianluca
Eden, Matthias
Botta, Beate
Bramlage, Peter
De Paulis, Ruggero
Facultad/Departamentos/Servicios: Facultades, Departamentos, Servicios y Escuelas::Departamentos de la UMU::Cirugía, Pediatría y Obstetricia y Ginecología
Versión del editor: https://academic.oup.com/ejcts/article/60/3/681/6190381?login=true
URI: http://hdl.handle.net/10201/143183
DOI: https://doi.org/10.1093/icvts/ivad115
Tipo de documento: info:eu-repo/semantics/article
Número páginas / Extensión: 11
Derechos: info:eu-repo/semantics/openAccess
Atribución 4.0 Internacional
Descripción: © The Author(s) 2023. This manuscript version is made available under the CC-BY 4.0 license http://creativecommons.org/licenses/by/4.0/. This document is the Published version of a Published Work that appeared in final form in Interdisciplinary CardioVascular and Thoracic Surgery. To access the final edited and published work see https://doi.org/10.1093/icvts/ivad115
Aparece en las colecciones:Artículos: Cirugía, Pediatría y Obstetricia y Ginecología

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