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Título: | Bartonella Endocarditis in Spain: Case Reports of 21 Cases |
Fecha de publicación: | 10-may-2022 |
Editorial: | Multidisciplinary Digital Publishing Institute (MDPI) |
Cita bibliográfica: | Pathogens 2022, 11(5), 561 |
ISSN: | Electronic: 2076-0817 |
Palabras clave: | Infective endocarditis Blood culture negative endocarditis Bartonella endocarditis Bartonella spp |
Resumen: | Blood culture negative endocarditis (BCNE) is frequent in infective endocarditis (IE). One of the causes of BCNE is fastidious microorganisms, such as Bartonella spp. The aim of this study was to describe the epidemiologic, clinical characteristics, management and outcomes of patients with Bartonella IE from the “Spanish Collaboration on Endocarditis-Grupo de Apoyo al Manejo de la Endocarditis infecciosa en España (GAMES)”cohort. Here we presented 21 cases of Bartonella IE. This represents 0.3% of a total of 5590 cases and 2% of the BCNE from the GAMES cohort. 62% were due to Bartonella henselae and 38% to Bartonella quintana. Cardiac failure was the main presenting form (61.5% in B. hensalae, 87.5% in B. quintana IE) and the aortic valve was affected in 85% of the cases (76% in B. henselae, 100% in B. quintana IE). Typical signs such as fever were recorded in less than 40% of patients. Echocardiography showed vegetations in 92% and 100% of the patients with B. henselae and B. quintana, respectively. Culture was positive only in one patient and the remaining were diagnosed by serology and PCR. PCR was the most useful tool allowing for diagnosis in 16 patients (100% of the studied valves). Serology, at titers recommended by guidelines, only coincided with PCR in 52.4%. Antimicrobial therapy, in different combinations, was used in all cases. Surgery was performed in 76% of the patients. No in-hospital mortality was observed. One-year mortality was 9.4%. This article remarks the importance for investigating the presence of Bartonella infection as causative agent in all BCNE since the diagnosis needs specific microbiological tools and patients could benefit of a specific treatment. |
Autor/es principal/es: | García-Álvarez, Lara García-García, Concepción Muñoz, Patricia Fariñas-Álvarez, María del Carmen Gutiérrez Cuadra, Manuel Fernández-Hidalgo, Nuria García-Vázquez, Elisa Moral-Escudero, Encarnación Alonso-Socas, María del Mar García-Rosado, Dácil Hidalgo-Tenorio, Carmen Domínguez, Fernando Goikoetxea-Agirre, Josune Gainzarain, Juan Carlos Rodríguez-Esteban, María Ángeles Bosch-Guerra, Xerach Oteo, José A. Grupo de Apoyo al Manejo de la Endocarditis infecciosa en España (GAMES) |
Facultad/Departamentos/Servicios: | Facultades, Departamentos, Servicios y Escuelas::Departamentos de la UMU::Medicina Interna |
Versión del editor: | https://www.mdpi.com/2076-0817/11/5/561 |
URI: | http://hdl.handle.net/10201/142680 |
DOI: | https://doi.org/10.3390/pathogens11050561 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 14 |
Derechos: | info:eu-repo/semantics/openAccess Atribución 4.0 Internacional |
Descripción: | ©2022 by the authors.Licensee MDP. This manuscript version is made available under the CC-BY license http://creativecommons.org/licenses/by/4.0/. This document is the Published, version of a Published Work that appeared in final form in Pathogens . To access the final edited and published work see https://doi.org/10.3390/pathogens11050561 |
Matería geográfica: | Spain |
Aparece en las colecciones: | Artículos: Medicina |
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Bartonella Endocarditis in Spain.pdf | 319,11 kB | Adobe PDF | Visualizar/Abrir |
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