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Título: | Metallic ion content and damage to the DNA in oral mucosacells of children with fixed orthodontic appliances |
Fecha de publicación: | 6-abr-2011 |
Editorial: | Springer |
Cita bibliográfica: | Biometals (2011) 24:935–941 |
ISSN: | Print: 0966-0844 Electronic: 1572-8773 |
Palabras clave: | Orthodontic alloy Metal toxicity ICP-MS DNA damage Comet assay |
Resumen: | Although the metal devices used in orthodontic treatments are manufactured highly resistance to corrosion, they may still suffer some localized corrosion resulting from the oral cavity conditions. The corrosion causes the release of metals from the alloys used for their manufacture. In this report, we evaluated the in vivo metal ions release of three alloys (stainless steel, titanium and nickel-free) usually used in the orthodontics treatments and its genotoxicity. We applied to 15 patients, between 12 and 16 years, 4 tubes and 20 brackets. Samples from oral mucosa were taken before the treatment and 30 days later. The concentration of the titanium, chromium, manganese, cobalt, nickel, molybdenum and iron were detected using inductively coupled plasma mass spectrometry (ICP-MS). The genotoxicity was measured with a comet assay (Olive moment). The oral mucosa cells in contact with the stainless steel alloy displayed the greatest titanium and manganese concentrations and those in contact with the nickel-free alloy presented the greatest concentration of chromium and iron. Both alloys, stainless steel and nickel-free, induced a higher DNA damage in the oral mucosa cells than the titanium alloy, in which the Olive moment was similar to controls. Based on the results of our study, we can conclude that titanium brackets and tubes are the most biocompatible of the three alloys. |
Autor/es principal/es: | Fernández Miñano, Esther Ortiz Ruiz, María Clara Vicente, Ascensión Calvo Guirado, José Luis Ortiz Ruiz, Antonio José |
Facultad/Departamentos/Servicios: | Facultades, Departamentos, Servicios y Escuelas::Departamentos de la UMU::Dermatología, Estomatología, Radiología y Medicina Física |
Versión del editor: | https://link.springer.com/article/10.1007/s10534-011-9448-z |
URI: | http://hdl.handle.net/10201/142633 |
DOI: | https://doi.org/10.1007/s10534-011-9448-z |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 7 |
Derechos: | info:eu-repo/semantics/embargoedAccess |
Descripción: | © Springer Science+Business Media, LLC. 2011. This document is the Published version of a Published Work that appeared in final form in BioMetals. To access the final edited and published work see https://doi.org/10.1007/s10534-011-9448-z |
Aparece en las colecciones: | Artículos: Dermatología, Estomatología, Radiología y Medicina Física |
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