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Título: | Functionalized Nanoplastics (NPs) Increase the Toxicity of Metals in Fish Cell Lines |
Fecha de publicación: | 2021 |
Fecha de defensa / creación: | 2021 |
Editorial: | MDPI (Basel, Switzerland) |
Cita bibliográfica: | International Journal of Molecular Science 2021, 22, 7141. |
ISSN: | Print: 1661-6596 Electronic: 1422-0067 |
Materias relacionadas: | CDU::5 - Ciencias puras y naturales |
Palabras clave: | Gilthead seabream Cell lines Nanoplastics Metals Fish |
Resumen: | Nanoplastics (NPs) are one of the most abundant environment‐threatening nanomaterials on the market. The objective of this study was to determine in vitro if functionalized NPs are cytotoxic by themselves or increase the toxicity of metals. For that, we used 50 nm polystyrene nanoparticles with distinct surface functionalization (pristine, PS‐Plain; carboxylic, PS‐COOH; and amino PS‐NH2) alone or combined with the metals arsenic (As) and methylmercury (MeHg), which possess an environmental risk to marine life. As test model, we chose a brain‐derived cell line (SaB‐1) from gilthead seabream (Sparus aurata), one of the most commercial fish species in the Mediterranean. First, only the PS‐NH2 NPs were toxic to SaB‐1 cells. NPs seem to be internalized into the cells but they showed little alteration in the transcription of genes related to oxidative stress (nrf2, cat, gr, gsta), cellular protection against metals (mta) or apoptosis (bcl2, bax). However, NPs, mainly PSCOOH and PS‐NH2, significantly increased the toxicity of both metals. Since the coexistence of NPs and other pollutants in the aquatic environment is inevitable, our results reveal that the combined effect of NPs with the rest of pollutants deserves more attention. |
Autor/es principal/es: | González Fernández, Carmen Díaz Baños, F. Guillermo Esteban, María Ángeles Cuesta, Alberto |
Facultad/Departamentos/Servicios: | Facultades, Departamentos, Servicios y Escuelas::Departamentos de la UMU::Química Física |
Versión del editor: | https://www.mdpi.com/1422-0067/22/13/7141 |
URI: | http://hdl.handle.net/10201/138714 |
DOI: | https://doi.org/10.3390/ijms22137141 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 16 |
Derechos: | info:eu-repo/semantics/openAccess Attribution-NonCommercial-NoDerivatives 4.0 Internacional |
Descripción: | Copyright: © 2021 by the authors. Li‐ censee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and con‐ ditions of the Creative Commons At‐ tribution (CC BY) license (http://crea‐ tivecommons.org/licenses/by/4.0/). |
Aparece en las colecciones: | Artículos: Química Física |
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