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10.3389/fnana.2023.1098352
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Título: | Molecular identity of the lateral lemniscus nuclei in the adult mouse brain |
Fecha de publicación: | 9-mar-2023 |
Editorial: | Frontiers Media |
Cita bibliográfica: | Front. Neuroanat., 2023 Volume 17 - 1098352 |
ISSN: | Electrónico: 1662-5129 |
Palabras clave: | Aauditory pathway Hearing pathway Cochlear nuclei Superior olive Iinferior colliculus, Gene expression |
Resumen: | The dorsal (DLL), intermediate (ILL), and ventral (VLL) lateral lemniscus nuclei are relay centers in the central auditory pathway of the brainstem, commonly referred to as the lateral lemniscus nuclei (LLN). The LLN are situated in the prepontine and pontine hindbrain, from rhombomeres 1 to 4, extending from the more rostral DLL to the caudal VLL, with the ILL lying in between. These nuclei can be distinguished morphologically and by topological and connectivity criteria, and here, we set out to further characterize the molecular nature of each LLN. We searched in situ hybridization studies in the Allen Mouse Brain Atlas for genes differentially expressed along the rostrocaudal axis of the brainstem, identifying 36 genes from diverse functional families expressed in the LLN. Available information in the databases indicated that 7 of these 36 genes are either associated with or potentially related to hearing disorders. In conclusion, the LLN are characterized by specific molecular profiles that reflect their rostrocaudal organization into the three constituent nuclei. This molecular regionalization may be involved in the etiology of some hearing disorders, in accordance with previous functional studies of these genes. |
Autor/es principal/es: | García-Guillén, Isabel M. Aroca, Pilar Marín, Faustino |
Facultad/Departamentos/Servicios: | Facultades, Departamentos, Servicios y Escuelas::Departamentos de la UMU::Anatomía Humana y Psicobiología |
URI: | http://hdl.handle.net/10201/135730 |
DOI: | 10.3389/fnana.2023.1098352 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 14 |
Derechos: | info:eu-repo/semantics/openAccess |
Descripción: | © 2023 García-Guillén, Aroca and Marín. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) http://creativecommons.org/licenses/by- /4.0/. The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. This document is the Published version of a Published Work that appeared in final form in Frontiers in Neuroanatomy. To access the final edited and published work see https://doi.org/10.3389/fnana.2023.1098352 |
Aparece en las colecciones: | Artículos: Anatomía Humana y Psicobiología |
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Molecular Identity-2023.pdf | 12,65 MB | Adobe PDF | Visualizar/Abrir |
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