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https://doi.org/10.14670/HH-18-566
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Título: | Sex differences in vanadium inhalation effects in non-ciliated bronchiolar cells |
Fecha de publicación: | 2023 |
Editorial: | Universidad de Murcia. Departamento de Biología Celular e Histología |
Cita bibliográfica: | Histology and Histopathology, Vol.38, nº7, (2023) |
ISSN: | 0213-3911 1699-5848 |
Materias relacionadas: | CDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología |
Palabras clave: | Vanadium Bronchiole Mucosecretory Lung Sex differences Non-ciliated bronchiolar cell |
Resumen: | The non-ciliated bronchiolar cell (NCBC) is responsible for the defense of the lung and responds to negative stimuli such as exposure to toxic pro-oxidant substances, which triggers the hyperproduction and hypersecretion of mucins and CC16 protein. The literature demonstrates that physiological and pathological responses in the lung can be influenced by the organism’s sex. The objective of this report was to evaluate response differences to vanadium inhalation in male and female CD-1 mice. Mice were exposed to vanadium for four weeks. Hyperplasia of bronchiolar epithelium, small inflammatory foci and sloughing of the NCBC were observed, without changes between sexes and throughout the exposure time. Mucosecretory metaplasia was found in both males and females, however it was more drastic in males. The expression of CC16 increased in both sexes. This study demonstrated a different susceptibility between male and female mice exposed to vanadium inhalation regarding mucosecretory metaplasia. |
Autor/es principal/es: | López Valdez, Nelly Rojas Lemus, Marcela Bizarro Nevares, Martha Patricia González Villalva, Adriana Elizabeth Ustarroz Cano, Martha Luz Casarrubias Tabarez, Brenda Guerrero Palomo, Gabriela Cervantes Valencia, María Eugenia Rivera Fernández, Norma Imelda Fortoul, Teresa |
URI: | http://hdl.handle.net/10201/133687 |
DOI: | https://doi.org/10.14670/HH-18-566 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 13 |
Derechos: | info:eu-repo/semantics/openAccess Attribution-NonCommercial-NoDerivatives 4.0 Internacional |
Aparece en las colecciones: | Vol.38, nº7 (2023) |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
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Lopez-Valdez-38-765-777-2023.pdf | 9,87 MB | Adobe PDF | Visualizar/Abrir |
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