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https://doi.org/10.14670/HH-18-215
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Título: | PSMA expression on neovasculature of solid tumors |
Fecha de publicación: | 2020 |
Editorial: | Universidad de Murcia, Departamento de Biologia Celular e Histiologia |
Cita bibliográfica: | Histology and Histopathology Vol. 35, nº9 (2020) |
ISSN: | 0213-3911 1699-5848 |
Materias relacionadas: | CDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología |
Palabras clave: | PSMA Neovasculature Solid tumors |
Resumen: | The use of prostate specific membrane antigen (PSMA) binding agents, labelled with diagnostic and therapeutic radio-isotopes is opening the potential for a new era of personalized management of prostate carcinoma. A wide variety of immuno- histochemistry studies have shown PSMA also to be upregulated on the endothelial cells of the neovasculature of a wide variety of other solid tumors where it may facilitate endothelial cell sprouting and invasion through its regulation of lytic proteases that have the ability to cleave the extracellular matrix. Similar to the introduction of PSMA-targeting theranostics in prostate carcinoma, overexpression of PSMA on newly formed tumor vessels may serve as a target for imaging and subsequent treatment of cancer through the use of agents that are capable of blocking PSMA in its function or through PSMA-mediated delivery of chemotherapeutics or radiation agents. In this review, the available data on PSMA expression on tumor neovasculature in human solid tumors assessed by using immunohistochemistry are discussed |
Autor/es principal/es: | Wiele, Christophe Van de Sathekge, Mike Spiegeleer, Bart de Jonghe, Pieter Jan De Debruyne, Philip R. Borms, Marleen Beels, Laurence Maes, Alex |
URI: | http://hdl.handle.net/10201/126203 |
DOI: | https://doi.org/10.14670/HH-18-215 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 9 |
Derechos: | info:eu-repo/semantics/openAccess Attribution-NonCommercial-NoDerivatives 4.0 Internacional |
Aparece en las colecciones: | Vol.35, nº9 (2020) |
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Fichero | Descripción | Tamaño | Formato | |
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Van-de-Wiele-35-919-927-2020.pdf | 537,32 kB | Adobe PDF | Visualizar/Abrir |
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