Por favor, use este identificador para citar o enlazar este ítem:
10.1126/science.aay1436
Twittear
Título: | A bacterial light response reveals an orphan desaturase for human plasmalogen synthesis |
Fecha de defensa / creación: | 4-oct-2019 |
Cita bibliográfica: | Science. 2019 Oct 4;366(6461):128-132 |
ISSN: | 1095-9203 0036-8075 |
Materias relacionadas: | CDU::5 - Ciencias puras y naturales |
Palabras clave: | Plasmanylethanolamine desaturase TMEM189 Plasmalogen Light-induced carotenogenesis Photooxidative stress Myxococcus xanthus Ether lipids |
Resumen: | Plasmalogens are glycerophospholipids with a hallmark sn-1 vinyl ether bond. These lipids are found in animals and some bacteria and have proposed membrane organization, signaling, and antioxidant roles. We discovered the plasmanylethanolamine desaturase activity essential for vinyl ether bond formation in a bacterial enzyme, CarF, which is a homolog of the human enzyme TMEM189. CarF mediates light-induced carotenogenesis in Myxococcus xanthus, and we found that plasmalogens participate in sensing photooxidative stress through singlet oxygen. TMEM189 and other animal homologs could functionally replace CarF in M. xanthus, and knocking out of TMEM189 in a human cell line eliminated plasmalogens. Discovery of the human plasmanylethanolamine desaturase will spur further study of plasmalogen biogenesis, functions, and roles in disease. |
Autor/es principal/es: | Gallego García, Aránzazu Monera-Girona, Antonio Pajares-Martínez, Elena Bastida-Martínez, Eva Pérez-Castaño, Ricardo Iniesta Martínez, Antonio Ángel Fontes Bastos, Marta Padmanabhan, S. Elías Arnanz, Montserrat |
Facultad/Departamentos/Servicios: | Facultades, Departamentos, Servicios y Escuelas::Departamentos de la UMU::Genética y Microbiología |
URI: | http://hdl.handle.net/10201/103103 |
DOI: | 10.1126/science.aay1436 |
Tipo de documento: | info:eu-repo/semantics/article |
Derechos: | info:eu-repo/semantics/openAccess |
Aparece en las colecciones: | Artículos: Genética y Microbiología |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
aay1436_ArticleContent.pdf | 4,82 MB | Adobe PDF | Visualizar/Abrir |
Los ítems de Digitum están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.