Publication: Expression and prognostic significance of YAP, TAZ, TEAD4 and p73 in human laryngeal cancer
Authors
Tsinias, Georgios ; Nikou, Sofia ; Mastronikolis, Nicholas ; Bravou, Vasiliki ; Papadaki, Helen
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Publisher
Universidad de Murcia, Departamento de Biologia Celular e Histiologia
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DOI
https://doi.org/10.14670/HH-18-228
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info:eu-repo/semantics/article
Description
Abstract
Objectives. The Hippo signaling pathway
plays a critical role in organ size control and tissue
homeostasis and its perturbation is associated with
tumorigenesis. YAP (Yes associated protein) and TAZ
(transcriptional co-activator with PDZ- binding motif)
are the major nuclear effectors of the Hippo pathway
interacting with TEADs (TEA domain) and p73
transcriptional factors to regulate gene expression.
Altered expression of the above proteins promotes tumor
initiation, progression and metastasis in a variety of
cancer types. This study addresses their expression and
prognostic significance in human laryngeal carcinoma.
Methods. Protein expression of YAP, TAZ, TEAD4 and
p73 was examined by immunohistochemistry in 121
human laryngeal squamous cell carcinomas. Correlations
with clinicopathological data and survival were
evaluated. Results. All proteins were overexpressed in
human laryngeal carcinomas compared to non-neoplastic
adjacent epithelium. High expression of YAP, TAZ,
TEAD4 and p73 correlated significantly with high grade,
advanced stage, supraglottic location of tumor, nodal
metastases and recurrence. Furthermore, high expression
of all proteins was significantly associated with poor
overall and disease- free survival. p73 expression proved
to be an independent predictive factor of survival and
YAP expression proved to be an independent predictive
factor of disease recurrence. Conclusions. Deregulation
of the expression of the Hippo pathway proteins is
implicated in human laryngeal carcinogenesis and YAP
and p73 have prognostic significance in the outcome of
the disease
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