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Progress of research on engineered extracellular vesicles from different sources for disease treatment

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dc.contributor
dc.contributor.authorKang Jinhui
dc.contributor.authorWen Jun
dc.contributor.authorChen Huifang
dc.contributor.authorZhu Cui
dc.contributor.authorBai Yinshan
dc.contributor.departmentBiología Celular e Histología
dc.date.accessioned2025-10-17T11:59:15Z
dc.date.available2025-10-17T11:59:15Z
dc.date.issued2025
dc.description.abstractExtracellular vesicles (EVs) are lipid bilayer nanoparticles that encapsulate proteins, lipids, nucleic acids, and small molecules and display low immunogenicity, high stability, and cross-species transmission. By applying engineering technologies, the surface of EVs can be modified and loaded with cargo with therapeutic properties. Thus, engineered EVs can play important roles in preventing and treating various diseases. However, many challenges and uncertainties are faced in the clinical translation of EVs. In this review, we comprehensively analyzed the types of EVs derived from animal cells, plant cells, and microorganisms and summarized their biological properties and potential for engineering modifications. Furthermore, we also explored their therapeutic potential and discussed recent advancements in relevant clinical trials, aiming to provide scientific guidance for future research on the engineering of EVs and precision treatment of clinical diseases
dc.formatapplication/pdf
dc.format.extent18
dc.identifier.doihttps://doi.org/10.14670/HH-18-903
dc.identifier.eissn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/167392
dc.languageeng
dc.publisherUniversidad de Murcia, Departamento de Histología e Histopatología
dc.relationSin financiación externa a la Universidad
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectExtracellular vesicles
dc.subjectCargos
dc.subjectEngineering modification
dc.subjectDisease treatment
dc.subjectClinical trial
dc.subject.odsNo relacionado con ningún objetivo de desarrollo sostenible
dc.titleProgress of research on engineered extracellular vesicles from different sources for disease treatment
dc.typeinfo:eu-repo/semantics/article
dspace.entity.typePublication
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Histology and histopathology Vol.40,nº10 (2025)