Publication: Luteinizing hormone on Leydig cell structure and function
Authors
Mendis-Handagama, S.M.L.C.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The effects of luteinizing hormone (LH) and
human chorionic gonadotrophic hormone (hCG) on
Leydig cell structure and function are reviewed in this
paper under two main headings; responses to LH and
hCG stimulation and responses to LH deprivation. With
acute LH stimulation, up to 2 hours following the LH
injection, there was no change in the volume of a Leydig
cell. However, Leydig cell peroxisomal volume and
intraperoxisomal SCP2 content showed a rapid and
transient change. These changes can be considered to be
specific because: i) no other Leydig cell organelle
including smooth endoplasmic reticulum (SER) showed
such a change, and ii) only the intraperoxisomal SCP
but not catalase (a marker enryme for peroxisome~
showed such a change within 30 minutes of LH
stimulation. As these changes occurred prior to the peak
testosterone levels following this treatment, it is
suggested that SCP2 and peroxisomes may have an
association with testosterone biosynthesis prior to
cholesterol transport into mitochondria. With LH or hCG
stimulation for longer periods, i.e. one day or more, the
same morphological changes are produced in Leydig
cells irrespective of the age of the species, dosage of LH
or hCG, and with single or multiple doses. These
changes include, Leydig cell hypertrophy andlor
hyperplasia, increase in the cellular organelle content
(mostly SER and mitochondria) and depletion of lipid
droplets. In addition, a recent study showed that Leydig
cell peroxisomal volume, SCP2 content, the amount of
intraperoxisomal SCP2 and testosterone secretory
capacity were also significantly increased in response to
chronic LH treatment. The effects of LH deprivation by
whatever means (e.g. hypophysectomy, with testosterone
and 17B-estradiol Silastic implants, LH antisera) on
Leydig cell structure and function is generally described
as opposite to those observed following LH or hCG
stimulation. These include Leydig cell hypotrophy and
hypoplasia, reductions in the cytoplasmic organelle
content in general and specific reductions in SER and
peroxisomal volumes, reductions in total catalase and
Ofíprint requests to: Dr. S.M.L. Chamindrani Mendis-Handagama,
Department of Animal Science, College of Veterinary Medicine, The
Universiiy of Tennessee, Knoxville, Tennessee 37996, USA.
SCP2 in Leydig cells together with reductions in the
intraperoxisomal SCP2 content in Leydig cells and their
testosterone secretory capacity.
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