Publication: Identification of serotoninergic system components in stallion sperm
Authors
Jiménez Trejo, F. ; Coronado Mares, I. ; Boeta, M. ; González Santoyo, I. ; Vigueras Villaseñor, R. ; Arriaga Canon, C. ; Herrera, L.A. ; Tapia Rodríguez, M.
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Publisher
Universidad de Murcia. Departamento de Biología Celular e Histología
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DOI
DOI: 10.14670/HH-11-989
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info:eu-repo/semantics/article
Description
Abstract
Assisted reproductive techniques have been
used on several domestic animals to preserve desirable
traits in strains of high genetic and commercial value;
however in equines its efficiency rate is relatively low.
To increase the conception ratio in stallions, some
research groups have used pharmacological treatments
which promote sperm hyperactivation in order to
increase male’s fertility rates. In this way, our previous
work suggests that serotonin (5-HT) could be a good
pharmacological candidate that facilitates conception
rate in domestic horses. 5-HT is a neurohormone
involved in several reproductive processes, i.e., it
enhances hyperactivation, motility, and promotes the
acrosome reaction in mammalian sperm, but it has not
been described in the stallion sperm yet. Therefore,
using both immunofluorescence and western blot
techniques, we searched for and found some serotonin
markers such as 5-HT, 5-HT1B, 5-HT2A, 5-HT3
receptors, both TPH1 and MAOA enzymes, and
serotonin transporter (5-HTT) in stallion sperm. In
addition, we found a non-neuroendocrine cell, V-MAT1
transporter, which has not been previously reported in
mammalian sperm. Our results suggest that
serotoninergic system is present in stallion sperm, which
could be a pharmacological target to increase the
conception rates in domestic horses.
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Citation
Histology and Histopathology, Vol.33, nº9, (2018)
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