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Carcinosarcomas: tumors in transition?

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dc.contributor.authorSomarelli, Jason A.
dc.contributor.authorBoss, Mary-Keara
dc.contributor.authorEpstein, Jonathan I.
dc.contributor.authorArmstrong, Andrew J.
dc.contributor.authorGarcia-Blanco, Mariano A.
dc.date.accessioned2020-09-18T07:19:31Z
dc.date.available2020-09-18T07:19:31Z
dc.date.issued2015
dc.description.abstractCarcinosarcomas are rare, biphasic tumors that are comprised of carcinomatous and sarcomatous elements. While the exact mechanism by which these two phenotypes arise within a single tumor remains unclear, molecular evidence indicates that the epitheliod and spindle-cell components share a clonal origin. We propose that the biphasic nature of these neoplasms may represent an extreme case of epithelial plasticity, in which an epithelial-like cell undergoes a transition to a more mesenchymal phenotype. The present review will discuss both the histological and molecular biological evidence of the involvement of epithelial plasticity in driving the mixed phenotypes observed in carcinosarcomas.es
dc.formatapplication/pdfes
dc.format.extent15es
dc.identifier.citationHistology and Histopathology, vol. 30, nº 6, (2015)
dc.identifier.doi10.14670/HH-30.673
dc.identifier.issn1699-5848
dc.identifier.urihttp://hdl.handle.net/10201/96121
dc.languageenges
dc.publisherF. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histologíaes
dc.relationSin financiación externa a la universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectEpithelial-mesenchymal transitiones
dc.subjectMesenchymal-epithelial transitiones
dc.subjectSarcomatoid carcinomaes
dc.subjectEMTes
dc.subjectMETes
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titleCarcinosarcomas: tumors in transition?es
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.30, nº6 (2015)