Publication:
Carcinosarcomas: tumors in transition?

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Somarelli-30-673-687-2015.pdf(3.73 MB)
Date
2015
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Authors
Somarelli, Jason A. ; Boss, Mary-Keara ; Epstein, Jonathan I. ; Armstrong, Andrew J. ; Garcia-Blanco, Mariano A.
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Publisher
F. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histología
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DOI
10.14670/HH-30.673
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info:eu-repo/semantics/article
Description
Abstract
Carcinosarcomas are rare, biphasic tumors that are comprised of carcinomatous and sarcomatous elements. While the exact mechanism by which these two phenotypes arise within a single tumor remains unclear, molecular evidence indicates that the epitheliod and spindle-cell components share a clonal origin. We propose that the biphasic nature of these neoplasms may represent an extreme case of epithelial plasticity, in which an epithelial-like cell undergoes a transition to a more mesenchymal phenotype. The present review will discuss both the histological and molecular biological evidence of the involvement of epithelial plasticity in driving the mixed phenotypes observed in carcinosarcomas.
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Epithelial-mesenchymal transition , Mesenchymal-epithelial transition , Sarcomatoid carcinoma , EMT , MET
Citation
Histology and Histopathology, vol. 30, nº 6, (2015)
URI
http://hdl.handle.net/10201/96121
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Histology and histopathology Vol.30, nº6 (2015)
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