Publication: Role of OPG-RANKL-RANK axis on the vasculature
Authors
Papadopouli, Aikaterini E. ; Klonaris, Christos N. ; Theocharis, Stamatios E.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Vascular calcification, a degenerative process
considered in the past to be a passive procedure, has now
been suggested to be related to ossification. Many
proteins responsible for bone formation have been
identified on the arterial wall. The OPG/RANKL/RANK
axis, responsible for ossification and bone
mineralization, seems to play a major role in vasculature
and atherosclerosis. Mice lacking OPG gene present
osteoporosis and arterial calcification, while
overexpression of OPG gene leads to osteopetrosis. In
the present review the latest knowledge related to the
effects of the OPG/RANKL/RANK axis on vasculature,
including atherosclerosis, will be analyzed. The clinical
significance of circulating OPG and RANKL levels in
vascular diseases will also be referred.
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Citation
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