Publication: The angiogenesis promoter, proadrenomedullin Nterminal
20 peptide (PAMP), improves healing in both
normoxic and ischemic wounds either alone or in
combination with autologous stem/progenitor cells
Authors
García-Honduvilla, Natalio ; Cifuentes, Alberto ; Bellón, Juan Manuel ; Buján, Julia ; Martínez, Alfredo
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Publisher
F. Hernández y Juan F. Madrid. Universidad de Murcia. Departamento de Biología Celular e Histología
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DOI
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info:eu-repo/semantics/article
Description
Abstract
A combination of vascular pathologies and
other complicating factors results in chronic wounds
which constitute a serious burden for both patients and
national health systems, due to prolonged hospital stays,
high costs, and prolonged nursing staff dedication. Here
we investigate whether proadrenomedullin N-terminal
20 peptide (PAMP), a naturally occurring peptide of the
skin with antimicrobial and proangiogenic properties,
either alone or in combination with autologous skeletal
muscle stem/progenitor cells, acts as a wound healing
factor. The rabbit ear was chosen as a test system, since
it offers a reliable model for normoxic and ischemic
wounds. Topical treatments with PAMP, stem/progenitor
cells, or a combination of both, resulted in significant
improvements of healing, when compared to untreated
wounds. PAMP was very effective in promoting
reepithelialization and angiogenesis, whereas treatment
with stem/progenitor cells alone resulted in less wound
contraction. Interestingly, the combination of PAMP and
stem/progenitor cells, while maintaining angiogenic
potency, reverted to the contraction levels observed in
the untreated controls. Under ischemic conditions,
generalized necrosis of the dermis and the underlying
cartilage was observed in untreated wounds. Treatments
of these wounds with PAMP or stem/progenitor cells
allowed a timely recovery. In conclusion, PAMP either
alone or in combination with autologous stem/progenitor
cells may provide a useful tool for improving wound
healing both in normoxic and ischemic conditions.
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Citation
Histology and histopathology, Vol. 28, n.º 1 (2013)
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