Publication: Steroid hormones and bone
Authors
Huang, W.H. ; Zheng, M.H.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Steroid hormones have an important impact
on bone. The mechanism of steroid action on bone cells
is through an interaction with specific receptor proteins
in the target cells. Steroid receptors are a class of
molecules that function as both signal transducers and
transcription factors. The receptors each have similar
functional domains that are responsible for discrete
functions. The mechanism of receptor action is mediated
by both genomic and nongenomic pathways. It is
believed that in genomic pathway the steroid passes
through the cell membrane by passive diffusion and
binds to the receptor within the nucleus. Steroids have
direct action on osteoblasts via receptor, and the effects
of steroids on osteoclastic bone resorption are mediated
through osteoblasts which release soluble factors by
the action of hormone-receptor binding. However,
in addition to indirect effects on osteoclasts, the
question whether steroid hormones could exert direct
action on osteoclasts as well has not to be answered
and findings to date are controversial. It is not
doubt that understanding the precise molecular
mechanism of steroid action on bone resorption
will develop new approaches for the diagnosis and
treatment of disease associated with osteoclastic bone
resorption.
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