Publication: Infant gut microbiota colonization: influence of prenatal and postnatal factors, focusing on diet
Authors
Clara Suárez-Martínez ; Marina Santaella-Pascual ; Genoveva Yagüe-Guirao ; Carmen Martínez-Graciá
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Facultades de la UMU::Facultad de Veterinaria
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Publisher
Frontiers Media
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DOI
10.3389/fmicb.2023.1236254
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info:eu-repo/semantics/article
Description
Abstract
Maternal microbiota forms the first infant gut microbial inoculum, and perinatal
factors (diet and use of antibiotics during pregnancy) and/or neonatal factors,
like intra partum antibiotics, gestational age and mode of delivery, may influence
microbial colonization. After birth, when the principal colonization occurs, the
microbial diversity increases and converges toward a stable adult-like microbiota
by the end of the first 3–5 years of life. However, during the early life, gut microbiota
can be disrupted by other postnatal factors like mode of infant feeding, antibiotic
usage, and various environmental factors generating a state of dysbiosis. Gut
dysbiosis have been reported to increase the risk of necrotizing enterocolitis and
some chronic diseases later in life, such as obesity, diabetes, cancer, allergies,
and asthma. Therefore, understanding the impact of a correct maternal-to-infant
microbial transfer and a good infant early colonization and maturation throughout
life would reduce the risk of disease in early and late life. This paper reviews the
published evidence on early-life gut microbiota development, as well as the
different factors influencing its evolution before, at, and after birth, focusing on
diet and nutrition during pregnancy and in the first months of life.
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gut microbiota , breast-feeding , diet , delivery mode , colonization , pregnancy , newborn , infant
Citation
Front. Microbiol. 14:1236254.
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