Publication: Dendritic cells, sentinels against pathogens
Authors
Chung, N.P.I. ; Chen, Y. ; Chan, Vera S.F. ; Tam, P.K.H. ; Lin, C.L.S.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Dendritic cells (DCs) are the most potent
antigen-presenting cells, and are regarded as “natural
adjuvants” for the induction of primary T or T-dependent
immunity. DCs in the peripheral sites capture and
process antigens. Encounter of exogenous or
endogenous stimuli mature the function of DCs, and
they thus acquire T-cell stimulatory capacity and distinct
chemotactic behavior which enables them to migrate to
lymphoid tissue. In the secondary lymphoid organs, they
present antigens to T- and B-cells and stimulate their
proliferation. Dendritic cells are also involved in
tolerance induction, in particular, to self antigens. DCs
also play a key role in the transmission of many
pathogens, and therefore may become targets for
designing new therapies. DCs have been manipulated in
vitro and in vivo for cancer immunotherapy. In this
article, we provide a concise overview of DC biology
and its current and future role in clinical settings.
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Citation
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