Publication:
Pretransplant CD28 Biomarker (Levels of Expression and Quantification of Molecules per Cell) in Peripheral CD4+ T Cells Predicts Acute Rejection Episodes in Liver and Kidney Recipients

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1-s2.0-S0041134516306662-main.pdf(243.11 KB)
Date
2016-11
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Authors
Eguía, J. ; González Martínez, G. ; De La Peña, J. ; Galian, J.A. ; Hernández Martínez, A.M. ; Moya Quiles, M.R. ; Legaz Pérez, Isabel ; Campillo, J.A. ; Ramírez, P. ; Sánchez Bueno, F. ; García Alonso, A.M. ; Pons, J.A. ; Minguela, A. ; Llorente, S. ; Muro, M. ; Bolarín, J.M.
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Publisher
Elsevier
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Ciencias Sociosanitarias
DOI
https://doi.org/10.1016/j.transproceed.2016.09.028
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info:eu-repo/semantics/article
Description
© 2016 Elsevier Inc. This document is the Published version of a Published Work that appeared in final form in Transplantation Proceedings. To access the final edited and published work see https://doi.org/10.1016/j.transproceed.2016.09.028
Abstract
Background Acute rejection (AR) remains a significant cause of graft loss. Better approaches to predict AR are being investigated. Surface CD28 protein is essential for T-cell proliferation and survival as well as cytokine production. Patients and Methods Pretransplant CD4+CD28+ peripheral T cells were examined in 30 liver recipients (LRs) and 31 kidney recipients (KRs) by flow cytometry. Results Pretransplant CD4+CD28+ T cells in LRs were significantly lower in rejectors than nonrejectors (P = .002). Furthermore, the total number of CD28 molecules per cell in LRs (P = .02) as well as KRs (P = .047) was significantly lower in rejectors than nonrejectors. The healthy group did not display differences when compared with patients with end-stage liver disease or renal failure; however, stratification analysis displayed higher levels of CD4+CD28+ when compared with rejected LRs (P = .04) but not KRs. CD28 levels <41.94% were able to discriminate LRs at high risk of AR (P = .003). Similarly, a total number of CD28 molecules ≤8359 (P = .031) in LRs and ≤7669 (P = .046) in KRs correlated with high risk of AR. Conclusion The preliminary results presented herein exhibit a fast and noninvasive method that assists clinicians to prevent AR by monitoring CD4+CD28+ peripheral T cells.
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Citation
Transplantation Proceedings, 2016, Vol. 48, Issue 9, pp. 2987-2989
URI
http://hdl.handle.net/10201/143026
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1-ene-2999
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