Publication: Comparison of functional glycans between cancer stem cells and normal stem cells
Authors
Sasaki, Norihiko ; Itakura, Yoko ; Gomi, Fujiya ; Hirano, Kazumi ; Toyoda, Masashi ; Ishiwata, Toshiyuki
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Publisher
Universidad de Murcia. Departamento de BiologĂa Celular e HistologĂa
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DOI
DOI: 10.14670/HH-18-119
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info:eu-repo/semantics/article
Description
Abstract
Cancer stem cells (CSCs) are a small group
of cells within a tumor that preserve stemness and
enhance regrowth of cancer cells. CSCs have important
implications in resistance to conventional therapies and
tumor relapse, although their detailed properties remain
unknown. Thus, CSCs represent promising targets to
improve cancer treatment. So far, a number of cell
surface markers containing glycans have been exploited
to identify and isolate CSCs. Cell surface glycans are
well-known markers for specific cell types and also play
important cellular roles, such as regulation of cell
signaling. In normal stem cells, including embryonic and
tissue stem cells, glycan markers in an undifferentiated
state have been identified. These markers are mostly
known to regulate signaling pathways required for
maintenance of stemness. In contrast, CSC-specific
glycans have not been well characterized yet. In this
review, we summarize functional commonalities
between CSCs and normal stem cells in glycan-mediated
signaling pathways. Identification of CSC-specific
glycans may lead to early diagnosis and radical
treatment of cancer.
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Citation
Histology and Histopathology, Vol.34, nÂş9, (2019)
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Este Ătem está sujeto a una licencia Creative Commons. http://creativecommons.org/licenses/by-nc-nd/4.0/