Publication: Immune based therapies in cancer
Authors
Krüger, C. ; Greten, T.F. ; Korangy, F.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Immunotherapy of cancer has become a
more promising approach in the past decade.
Developments in both basic immunology and tumor
biology have increased our knowledge of the
interactions between the tumor cells and the immune
system. The molecular identification of tumor-associated
antigens and understanding of immunological pathways
have cleared the way for development of different
strategies for anti-tumor vaccines. The success of any
cancer vaccine relies on the induction of an effective
tumor-specific immune response to break tolerance and
to elicit a long lasting anti-tumor immunity. It is also
increasingly clear that the interactions of host-tumor are
quite complicated leading to tumor escape mechanisms,
which add another level of difficulty to this interaction.
This review will summarize the recent developments in
tumor immunotherapy as well as the clinical trials
addressing novel immunotherapeutic approaches to
cancer.
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Citation
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