Publication: Objective differential classification of thyroid lesions by nuclear quantitative assessment
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Date
1997
Authors
Artacho-Perula, E. ; Roldan-Villalobos, R. ; Blanco-García, F. ; Blanco Rodriguez, A.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Quantitative nuclear parameters estimated by
morphometric and stereological methods in combination
with discriminant analysis were used in order to evaluate
the diagnostic efficiency of thyroid lesions. This study
includes 55 patients with thyroid pathology. Samples of
follicular adenomas, follicular carcinoma, and papillary
carcinomas were exarnined by image analysis to obtain
size and form nuclear parameters. Stepwise discriminant
analyses were performed. There was an increase in
nuclear size from follicular adenomas to follicular
carcinomas, and a greater increase from follicular
carcinomas to papillary carcinomas. The increase was
more significant when the three-dimensional estimates
of the volume-weighted mean nuclear volume were
assessed. No significant differences between follicular
adenomas and follicular carcinomas were found with
respect to the nuclear form factors; however, a
significant increase in nuclear elongation and irregularity
was registered between follicular and papillary tumors
(pe0.01). The overall accuracy rate of discrimination
was 75% when the three lesions were included in the
analysis, with an efficiency of 85% for papillary
carcinoma samples. These percentages increased when
two lesion discrimination was performed. The worst
discrimination (69% of efficiency) was found between
follicular adenomas and follicular carcinomas.
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