Publication: Evaluation of the cyclin-dependent kinase inhibitor p21Cip1 in epithelial ovarian tumors
of low malignant potential and adenocarcinomas
Authors
Vassilopoulos, I. ; Korkolopoulou, P. ; Konstantinidou, A.E. ; Patsouris, Efstratios ; Eftichiadis, C. ; Thimara, I. ; Perdiki, M. ; Pavlakis, K. ; Agapitos, E. ; Davaris, P.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Objective: In view of the controversial
information on the significance of the cyclin-dependent
kinase inhibitor p21Cip1 in ovarian cancer, we conducted
a retrospective investigation to clarify the relationships
of this protein to proliferation rate, clinicopathological
variables and prognosis of epithelial ovarian tumors.
Methods: Paraffin-embedded tissue from 43 ovarian
tumors of low malignant potential (LMP) and 82
primary ovarian adenocarcinomas were stained
immunohistochemically for p21Cip1, p53 protein and Ki-
67 antigen (a marker of cell proliferation). Results:
p21Cip1 levels were significantly higher in LMP tumors
(p<0.001) as well as in early stage adenocarcinomas
(p=0.021) and those associated with minimal residual
disease (p=0.008). However, no relationship existed
between p21Cip1 expression and the proliferation rate of
adenocarcinomas or LMP tumors. In the vast majority of
LMP tumors p21Cip1 expression was not accompanied
by p53 accumulation. This p21Cip1-positive/p53-negative
phenotype prevailed in the early stage (p=0.026), lower
grade (p=0.018) adenocarcinomas as well as in those left
with minimal residual disease (p=0.059). In patients with
lower grade adenocarcinomas, decreased p21Cip1 expression was adversely related to poor overall survival
on its own (p=0.0500) and when combined with p53
protein overexpression (p=0.0323). In multivariate
analysis, only the stage remained as the independent
predictor of survival. Conclusions: Decreased p21Cip1
expression is related to several indicators of
aggressiveness in ovarian adenocarcinomas and seems to
be differentially regulated in LMP tumors and
adenocarcinomas. On the contrary, deregulation of
p21Cip1 expression does not seem to participate in the
pathogenesis of LMP tumors. Furthermore, although
p21Cip1 alone or combined with p53 is of prognostic
significance in lower grade adenocarcinomas, it does not
appear to add to the information gained from traditional prognosticators.
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