Publication: Expression of tropomyosins in lung cancer - a potential role in carcinogenesis and its utility in a histopathological diagnosis
Authors
Okudela, Koji ; Mitsui, Hideaki ; Woo, Tetsukan ; Kojima, Yoko ; Matsumura, Mai ; Arai, Hiromasa ; Suzuki, Takehisa ; Umeda, Shigeaki ; Saito, Yuichi ; Tajiri, Michihiko ; Masuda, Munetaka ; Kameda, Yoichi ; Ohashi, Kenichi
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Publisher
Universidad de Murcia. Departamento de BiologĂa Celular e HistologĂa
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DOI
DOI: 10.14670/HH-11-721
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info:eu-repo/semantics/article
Description
Abstract
We herein analyzed the relationships
between tropomyosin protein expression levels and
clinicopathological factors in order to determine the
significance of tropomyosins in lung cancers. Although
neoplastic cells expressed different isoforms of
tropomyosin, overall expression levels were lower than
those in bronchial and alveolar epithelial cells. In
adenocarcinomas, tropomyosin levels were markedly
reduced in poorly differentiated or solid subtype
carcinomas, suggesting that a loss in the expression of
tropomyosins is involved in the progression of lung
adenocarcinomas. The potential utility of the immunohistochemical expression of tropomyosins for a
histopathological diagnosis was also investigated. The
sensitivity and specificity of a loss in the expression of
tropomyosins were 100% and 50%, respectively, which
were superior to those for the strong expression of p53
(sensitivity 100% and specificity 44%), a conventional
biomarker. An immunohistochemical examination of
tropomyosins may assist in the histopathological
detection of lung cancer cells in small biopsy specimens.
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Citation
Histology and Histopathology, Vol.31, nÂş8, (2016)
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Este Ătem está sujeto a una licencia Creative Commons. http://creativecommons.org/licenses/by-nc-nd/4.0/